A PROTAC building block
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Pomalidomide 4'-alkylC6-amine (hydrochloride)

Item No. 39985

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(6-aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, monohydrochloride
CAS Number
2375194-37-7
Molecular Formula
C19H24N4O4 • HCl
Formula Weight
408.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(N1C(CCC2=O)C(N2)=O)C(C(C1=O)=CC=C3)=C3NCCCCCCN.Cl
InChi Code
InChI=1S/C19H24N4O4.ClH/c20-10-3-1-2-4-11-21-13-7-5-6-12-16(13)19(27)23(18(12)26)14-8-9-15(24)22-17(14)25;/h5-7,14,21H,1-4,8-11,20H2,(H,22,24,25);1H
InChi Key
PBGMRXNTLPSDNR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $83

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    50 mg

    $125

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    100 mg

    $231

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    Product Description

    Pomalidomide 4'-alkylC6-amine is a building block in the synthesis of proteolysis-targeting chimeras (PROTACs) and a derivative of the cereblon inhibitor pomalidomide (Item No. 19877).1 It has been used in the synthesis of PROTACs containing BRD73954 (Item No. 16919) that drive histone deacetylase 8 (HDAC8) degradation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, Z., Deng, B., Yang, Z., et al. Discovery of pomalidomide-based PROTACs for selective degradation of histone deacetylase 8. Eur. J. Med. Chem. 239, 114544 (2022).