A RARα antagonist
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YCT529

Item No. 39995

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(5-(2,2-dimethyl-4-(p-tolyl)-2H-chromen-6-yl)-1H-pyrrol-2-yl)benzoate, sodium salt
Synonyms
  • GPHR-00354529
Molecular Formula
C29H24NO3 • XNa
Formula Weight
434.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleDMSO: SolubleWater: Slightly soluble
SMILES
CC1(C=C(C(C=C2)=CC=C2C)C3=CC(C4=CC=C(C(C=C5)=CC=C5C([O-])=O)N4)=CC=C3O1)C.[Na+]
InChi Code
InChI=1S/C29H25NO3.Na/c1-18-4-6-19(7-5-18)24-17-29(2,3)33-27-15-12-22(16-23(24)27)26-14-13-25(30-26)20-8-10-21(11-9-20)28(31)32;/h4-17,30H,1-3H3,(H,31,32);/q;+1/p-1
InChi Key
NNFWFHLHNJSJTH-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $116

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    5 mg

    $376

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    Product Description

    YCT529 is an antagonist of retinoic acid receptor α (RARα; IC50 = 6.8 nM).1 It is selective for RARα over RARβ and RARγ (IC50s = >3,700 nM for both). YCT529 (7.5 mg/kg per week) reversibly reduces epidydimal sperm counts without reducing serum testosterone levels in male mice. It reduces germinal epithelial thickness in male dogs when administered at a dose of 25 mg/kg per day. YCT529 (10 mg/kg per week) decreases the number of embryos formed following copulation when administered to male rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Georg, G.I., and Cheryala, N. Contraceptive compounds and methods. (2022).