Mandipropamid

Mandipropamid is a carboxylic acid amide fungicide.^1,2 It inhibits cellulose synthesis and germ tube elongation in P. infestans when used at a concentration of 68 nM.¹ Mandipropamid reduces mycelial growth of Phytophthora and P. litchi (EC₅₀s = 0.008-0.03 mg/L).² It is toxic to zebrafish embryos, larvae, and adults (LC₅₀s = 19.91, 4.53, and 4.85 mg/L, respectively). Mandipropamid has been used as a chemical inducer of proximity to study protein translocation in vitro and in vivo.³ Formulations containing mandipropamid have been used as fungicides in agriculture.

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1. Blum, M., Boehler, M., Randall, E., et al. Mandipropamid targets the cellulose synthase-like PiCesA3 to inhibit cell wall biosynthesis in the oomycete plant pathogen, Phytophthora infestans. Mol. Plant Pathol. 11(2), 227-243 (2010).

2. Zhang, J., Wu, Q., Zhong, Y., et al. Enantioselective bioactivity, toxicity, and degradation in vegetables and soil of chiral fungicide mandipropamid. J. Agric. Food Chem. 69(45), 13416-13424 (2021).

3. Ziegler, M.J., Yserentant, K., Dunsing, V., et al. Mandipropamid as a chemical inducer of proximity for in vivo applications. Nat. Chem. Biol. 18(1), 64-69 (2022).