A triterpene saponin with diverse biological activities
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Astragaloside II

Item No. 40139

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,6α,16β,20R,24S)-3-[(2-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl, β-D-glucopyranoside
CAS Number
84676-89-1
Synonyms
  • Astrasieversianin VIII
  • NSC 641295
Molecular Formula
C43H70O15
Formula Weight
827.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]([C@]5(C)O[C@H](C(C)(O)C)CC5)([H])[C@H](C2)O)C)[C@@]6([C@@](C(C)([C@H](CC6)O[C@H]7[C@@H]([C@H]([C@@H](CO7)O)O)OC(C)=O)C)([H])[C@H](C3)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)C4
InChi Code
InChI=1S/C43H70O15/c1-20(45)54-32-28(48)22(47)18-53-36(32)57-26-10-12-43-19-42(43)14-13-39(6)33(41(8)11-9-27(58-41)38(4,5)52)21(46)16-40(39,7)25(42)15-23(34(43)37(26,2)3)55-35-31(51)30(50)29(49)24(17-44)56-35/h21-36,44,46-52H,9-19H2,1-8H3/t21-,22+,23-,24+,25-,26-,27-,28-,29+,30-,31+,32+,33-,34-,35+,36-,39+,40-,41+,42-,43+/m0/s1
InChi Key
AYWNHWGQTMCQIV-PENCHUSISA-N
Origin
Plant/Astragalus membranaceus (Fisch.) Bunge
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $120

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    10 mg

    $228

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    25 mg

    $541

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    50 mg

    $960

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    Product Description

    Astragaloside II is a triterpene saponin that has been found in A. membranaceus and has diverse biological activities.1,2,3,4,5 It increases the phosphatase activity of CD45 in cell-free assays using 4-nitrophenyl phosphate (pNPP; Item No. 34081) or OMFP as substrates (EC50s = 9.23 and 5.37 µg/ml, respectively).1 Astragaloside II inhibits replication of dengue virus serotypes 1 and 3 in infected Vero cells (MIC = 1.56 µg/ml for both).2 It increases concanavalin A-induced proliferation of primary mouse splenocytes when used at a concentration of 30 nM.1 Astragaloside II (50 µM) inhibits autophagy and enhances apoptosis induced by the DNA-crosslinking agent cisplatin (Item No. 13119) in SGC-7901 gastric cancer cells.3 It prevents decreases in small intestine and colon length, as well as body weight, in a mouse model of TNBS-induced colitis when administered at a dose of 10 mg/kg.4 Astragaloside II (3.2 and 6.4 mg/kg) decreases the urinary albumin-to-creatinine ratio and improves histopathological scores in a rat model of diabetic nephropathy induced by streptozotocin (STZ; Item No. 13104).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wan, C.-p., Gao, L.-x., Hou, L.-f., et al. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity. Acta Pharmacol. Sin. 34(4), 522-530 (2013).

    2. Indu, P., Arunagirinathan, N., Rameshkumar, M.R., et al. Antiviral activity of astragaloside II, astragaloside III and astragaloside IV compounds against dengue virus: Computational docking and in vitro studies. Microb. Pathog. 152, 104563 (2021).

    3. Yang, C., Wu, C., Xu, D., et al. AstragalosideII inhibits autophagic flux and enhance chemosensitivity of cisplatin in human cancer cells. Biomed. Pharmacother. 81, 166-175 (2016).

    4. Lee, S.-Y., Tsai, W.-C., Lin, J.-C., et al. Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway. Sci. Rep. 7(1), 12302 (2017).

    5. Su, J., Gao, C., Xie, L., et al. Astragaloside II ameliorated podocyte injury and mitochondrial dysfunction in streptozotocin-induced diabetic rats. Front. Pharmacol. 12, 638422 (2021).