A microbial metabolite with immunomodulatory activity
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Conagenin

Item No. 40222

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3,5-dideoxy-3-methyl-D-xylonoyl)-2-methyl-L-serine
CAS Number
134381-30-9
Synonyms
  • CNG
  • (+)-Conagenin
Molecular Formula
C10H19NO6
Formula Weight
249.3
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O[C@@H]([C@H](C)[C@@H](O)C(N[C@@](C)(CO)C(O)=O)=O)C
InChi Code
InChI=1S/C10H19NO6/c1-5(6(2)13)7(14)8(15)11-10(3,4-12)9(16)17/h5-7,12-14H,4H2,1-3H3,(H,11,15)(H,16,17)/t5-,6+,7+,10-/m0/s1
InChi Key
GLESHRYLRAOJPS-DHCFDGJBSA-N
Origin
Bacterium/Streptomyces roseosporus MI696-AF3
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 mg

    $468

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    Product Description

    Conagenin (CNG) is a microbial metabolite originally isolated from S. roseosporus that has immunomodulatory activity.1 It increases the proliferation of isolated rat splenic T cells induced by concanavalin A (Item No. 14951) when used at concentrations of 6.25 and 25 µg/ml. CNG (0.5 and 5 mg/kg) reduces tumor volume and increases the number of activated effector T cells in an IMC carcinoma mouse xenograft model.2 It also increases the phagocytic activity of isolated rat alveolar macrophages when administered at a dose of 10 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamashita, T., Iijima, M., Nakamura, H., et al. Conagenin, a low molecular weight immunomodulator produced by Streptomyces roseosporus. J. Antibiot. (Tokyo) 44(5), 557-559 (1991).

    2. Kawatsu, M., Yamashita, T., Osono, M., et al. Effect of conagenin in tumor bearing mice. Antitumor activity, generation of effector cells and cytokine production. J. Antibiot. (Tokyo) 46(11), 1692-1698 (1993).

    3. Hamada, M., Yamamoto, S., Moriguchi, S., et al. Phagocytosis of alveolar macrophages after conagenin injection to rats. J. Antibiot. (Tokyo) 54(4), 349-353 (2001).