An M2 TAM-targeting peptide
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M2 Peptide

Item No. 40263

Product Insert (PDF)
Technical Information
Synonyms
  • M2pep
  • TAM-targeting Peptide
MW
1,757.7
Formulation (Request formulation change)
1 mg of a lyophilized peptide trifluoroacetate salt
Peptide Sequence
YWWKVGWPDQEYC-NH2
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $329

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    Cayman Chemical
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    Product Description

    M2 peptide is an M2 tumor-associated macrophage-targeting peptide.1,2 It has been used in the generation of anticancer polymeric micelles encapsulating the STAT6 inhibitor AS1517499 (Item No. 29071) for delivery to M2 tumor-associated macrophages (TAMs) in vitro and in vivo. Cayman’s M2 Peptide is intended for use in peptide conjugation to lipid-based drug delivery platforms containing maleimide-activated lipids such as DSPE-PEG(2000) maleimide for TAM-targeting applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiao, H., Guo, Y., Li, B., et al. M2-like tumor-associated macrophage-targeted codelivery of STAT6 inhibitor and IKKβ siRNA induces M2-to-M1 repolarization for cancer immunotherapy with low immune side effects. ACS Cent. Sci. 6(7), 1208-1222 (2020).

    2. Huang, T., Zhang, Q., Yi, J., et al. PEG-sheddable nanodrug remodels tumor microenvironment to promote effector T cell infiltration and revise their exhaustion for breast cancer immunotherapy. Small 19(38), e2301749 (2023).