A triterpenoid with diverse biological activities
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Soyasapogenol B

Item No. 40270

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4β,22β)-olean-12-ene-3,22,23-triol
CAS Number
595-15-3
Synonyms
  • Soyasapogenin B
  • Soyasapogenol I
Molecular Formula
C30H50O3
Formula Weight
458.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly solubleDMSO: SolubleMethanol: Slightly soluble
SMILES
C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)([C@@H](CC(C)(C4)C)O)C)=CC[C@]1([H])[C@@]5([C@@]([C@](C)([C@H](CC5)O)CO)([H])CC2)C)C
InChi Code
InChI=1S/C30H50O3/c1-25(2)16-20-19-8-9-22-27(4)12-11-23(32)28(5,18-31)21(27)10-13-30(22,7)29(19,6)15-14-26(20,3)24(33)17-25/h8,20-24,31-33H,9-18H2,1-7H3/t20-,21+,22+,23-,24+,26+,27-,28+,29+,30+/m0/s1
InChi Key
YOQAQNKGFOLRGT-UXXABWCISA-N
Origin
Plant/Glycine max
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $87

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    5 mg

    $326

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    10 mg

    $522

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    25 mg

    $869

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    Product Description

    Soyasapogenol B is a triterpenoid that has been found in A. membranaceus and has diverse biological activities.1,2,3 It inhibits LPS-induced increases in the levels of nitric oxide (NO) in RAW 264.7 macrophages when used at a concentration of 95.6 µM.1 Soyasapogenol B (12.5 µM) decreases triglyceride levels, as well as increases glycerol and free fatty acids levels in, and decreases the levels of resistin secreted from, 3T3-L1 adipocytes.2 In vivo, soyasapogenol B (80 mg/kg) reduces plasma levels of alanine transaminase (ALT) in a mouse model of autoimmune hepatitis induced by concanavalin A (Item No. 14951).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, Z.B., Zhai, Y.D., Ma, Z.P., et al. Triterpenoids and flavonoids from the leaves of Astragalus membranaceus and their inhibitory effects on nitric oxide production. Chem. Biodivers. 12(10), 1575-1584 (2015).

    2. Iwamoto, K., Kamo, S., Takada, Y., et al. Soyasapogenols reduce cellular triglyceride levels in 3T3-L1 mouse adipocyte cells by accelerating triglyceride lipolysis. Biochem. Biophys. Rep. 16, 44-49 (2018).

    3. Sasaki, K., Minowa, N., Kuzuhara, H., et al. Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model. Bioorg. Med. Chem. 13(16), 4900-4911 (2005).