A flavonoid with diverse biological activities
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4',5,7-Trimethoxyflavone

Item No. 40271

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
5631-70-9
Synonyms
  • 5,7,4’-Trimethoxyflavone
  • Trimethylapigenin
  • Tri-O-methylapigenin
Molecular Formula
C18H16O5
Formula Weight
312.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(OC)=CC(OC)=C13
InChi Code
InChI=1S/C18H16O5/c1-20-12-6-4-11(5-7-12)15-10-14(19)18-16(22-3)8-13(21-2)9-17(18)23-15/h4-10H,1-3H3
InChi Key
ZXJJBDHPUHUUHD-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    4’,5,7-Trimethoxyflavone is a flavonoid that has been found in K. parviflora and has diverse biological activities.1,2,3 It inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by 47.1 and 46.2%, respectively, in a cell-free assay when used at a concentration of 0.1 mg/ml.1 4’,5,7-Trimethoxyflavone (1 and 10 µM) scavenges radicals in a Trolox equivalent antioxidant capacity (TEAC) assay.2 It inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells when used at a concentration of 10 µM. 4’,5,7-Trimethoxyflavone stimulates chloride secretion in Calu-3 human airway epithelial cells, which endogenously express cystic fibrosis transmembrane conductance regulator (CFTR) as their major apical chloride channel.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sawasdee, P., Sabphon, C., Sitthiwongwanit, D., et al. Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora. Phytother. Res. 23(12), 1792-1794 (2009).

    2. Thao, N.P., Luyen, B.T.T., Lee, S.H., et al. Anti-osteoporotic and antioxidant activities by rhizomes of Kaempferia parviflora Wall. ex Baker. Nat. Prod. Sci. 22(1), 13-19 (2016).

    3. Fischer, H., and Illek, B. Activation of the CFTR Cl- channel by trimethoxyflavone in vitro and in vivo. Cell. Physiol. Biochem. 22(5-6), 685-692 (2008).