An aporphine alkaloid with diverse biological activities
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N-Methylnuciferine (iodide)

Item No. 40276

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-5,6,6a,7-tetrahydro-1,2-dimethoxy-6,6-dimethyl-4H-dibenzo[de,g]quinolinium, monoiodide
CAS Number
53098-68-3
Molecular Formula
C20H24NO2 • I
Formula Weight
437.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
COC1=C2C3=C(C=C1OC)CC[N+](C)(C)[C@]3([H])CC4=CC=CC=C42.[I-]
InChi Code
InChI=1S/C20H24NO2.HI/c1-21(2)10-9-14-12-17(22-3)20(23-4)19-15-8-6-5-7-13(15)11-16(21)18(14)19;/h5-8,12,16H,9-11H2,1-4H3;1H/q+1;/p-1/t16-;/m1./s1
InChi Key
MEGZWDNQPAGXKQ-PKLMIRHRSA-M
Origin
Plant/Nelumbo nucifera Gaertn.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $58

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    5 mg

    $258

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    10 mg

    $487

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    25 mg

    $1,144

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    Product Description

    N-Methylnuciferine is an aporphine alkaloid that has been found in A. cherimola and has diverse biological activities.1,2 It scavenges DPPH (Item No. 14805) radicals (IC50 = 711.76 µg/ml) and inhibits α-glucosidase and α-amylase (IC50s = 2,627.78 and 1,818.18 µg/ml, respectively) in cell-free assays.1 N-Methylnuciferine (20 µM) reduces LPS-induced nitric oxide (NO) production in BV-2 microglia.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Galarce-Bustos, O., Obregón, C., Vallejos-Almirall, A., et al. Application of effect-directed analysis using TLC-bioautography for rapid isolation and identification of antidiabetic compounds from the leaves of Annona cherimola Mill. Phytochem. Anal. 34(8), 970-983 (2023).

    2. Chen, S., Guo, W., Qi, X., et al. Natural alkaloids from lotus plumule ameliorate lipopolysaccharide-induced depression-like behavior: Integrating network pharmacology and molecular mechanism evaluation. Food Funct. 10(9), 6062-6073 (2019).