A derivative of guanosine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

N2-Isobutyryl Guanosine

Item No. 40283

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-methyl-1-oxopropyl)-guanosine
CAS Number
64350-24-9
Molecular Formula
C14H19N5O6
Formula Weight
353.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
O=C(N=C(N1)NC(C(C)C)=O)C(N=C2)=C1N2[C@@H]3O[C@H](CO)[C@H]([C@H]3O)O
InChi Code
InChI=1S/C14H19N5O6/c1-5(2)11(23)17-14-16-10-7(12(24)18-14)15-4-19(10)13-9(22)8(21)6(3-20)25-13/h4-6,8-9,13,20-22H,3H2,1-2H3,(H2,16,17,18,23,24)/t6-,8-,9-,13-/m1/s1
InChi Key
OXTYJSXVUGJSGM-HTVVRFAVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 g

    $50

    Add

    10 g

    $90

    Add

    25 g

    $186

    Add

    50 g

    $297

    Add
    Product Description

    N2-Isobutyryl guanosine is a derivative of the nucleoside guanosine (Item No. 27702) containing an isobutyryl protecting group.1 It is a precursor in the synthesis of hydrophobic dinucleotide cap analogs used to purify capped mRNA and photocaged 3’-S-RNAs used in the study of ribozyme-catalyzed reactions.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Inagaki, M., Abe, N., Li, Z., et al. Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures. Nat. Commun. 14(1), 2657 (2023).

    2. Li, N.-S., Tuttle, N., Staley, J.P., et al. Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: Substrate for probing the mechanism of RNA catalysis. The Journal of Organic Chemistry 79(8), 3647-3652 (2014).