A dual inhibitor of USP25 and USP28
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AZ1 USP25/28 Inhibitor

Item No. 40335

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]-ethanol
CAS Number
2165322-94-9
Synonyms
  • AZ1 Ubiquitin-specific Protease 25/28 Inhibitor
Molecular Formula
C17H16BrF4NO2
Formula Weight
422.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
FC1=CC=C(COC2=CC=C(C=C2CNCCO)Br)C=C1C(F)(F)F
InChi Code
InChI=1S/C17H16BrF4NO2/c18-13-2-4-16(12(8-13)9-23-5-6-24)25-10-11-1-3-15(19)14(7-11)17(20,21)22/h1-4,7-8,23-24H,5-6,9-10H2
InChi Key
ITHSFXDGKQYOED-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $83

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    10 mg

    $132

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    25 mg

    $269

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    50 mg

    $413

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    Product Description

    AZ1 USP25/28 Inhibitor is a dual inhibitor of ubiquitin-specific protease 25 (USP25) and USP28 (IC50s = 0.7 and 0.6 µM, respectively).1 It is selective for USP25 and USP28 over USP2a (IC50 = >100 µM), a panel of 22 other deubiquitinases at 10 µM, and a panel of eight caspases and cathepsins at 30 µM. AZ1 USP25/28 Inhibitor induces degradation of c-Myc in HCT116 cells in a concentration-dependent manner, an effect that can be reversed by the proteasome inhibitor MG132. It decreases the viability of several cancer cell lines (EC50s = 9.8-33.5 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wrigley, J.D., Gavory, G., Simpson, I.A., et al. Identification and characterization of dual inhibitors of the USP25/28 deubiquitinating enzyme subfamily. ACS Chem. Biol. 12(12), 3113-3125 (2017).