An antiviral nucleoside analog and a prodrug form of GS-441524
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Active Metabolite(s)
30469GS-441524
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Obeldesivir

Item No. 40404

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile, 6-(2-methylpropanoate)
CAS Number
2647441-36-7
Synonyms
  • ATV006
  • GS-5245
Molecular Formula
C16H19N5O5
Formula Weight
361.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Slightly SolubleWater: Slightly Soluble
SMILES
N#C[C@@]1(C2=CC=C3N2N=CN=C3N)O[C@@H]([C@H]([C@H]1O)O)COC(C(C)C)=O
InChi Code
InChI=1S/C16H19N5O5/c1-8(2)15(24)25-5-10-12(22)13(23)16(6-17,26-10)11-4-3-9-14(18)19-7-20-21(9)11/h3-4,7-8,10,12-13,22-23H,5H2,1-2H3,(H2,18,19,20)/t10-,12-,13-,16+/m1/s1
InChi Key
YIHPGVCWGSURHO-VSBTWAGUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Cayman Chemical
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    Product Description

    Obeldesivir is an antiviral nucleoside analog and a prodrug form of GS-441524 (Item No. 30469).1 It inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV-2 Βeta, Gamma, or Omicron variants in infected Vero E6 cells (EC50s = 1.36, 1.127, 0.349, and 0.106 µM, respectively) with a 50% cytotoxicity concentration (CC50) value of 128 µM. Obeldesivir (250 or 500 mg/kg per day) reduces nucleocapsid guide RNA (gRNA) copy number and small-guide RNA (sgRNA) levels in the lungs of, and decreases lung damage in, a KI-hACE2 mouse model of SARS-CoV-2 infection. It reduces the levels of the spike glycoprotein (S protein), also known as the surface glycoprotein, in the lungs of, as well as decreases particle forming units (PFUs) in the lung tissues, reduces lung and spleen inflammation, and prevents viral infection-induced death in, a K18-hACE2 mouse model of SARS-CoV-2 infection when administered at doses of 100 or 250 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cao, L., Li, Y., Yang, S., et al. The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants. Sci. Transl. Med. 14(661), eabm7621 (2022).