A Certified Reference Material
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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Research Tool(s)
12014Haloperidol
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Haloperidol (CRM)

A 1 mg/ml solution in methanol

Item No. 40431

Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • McN-JR 1625
  • NSC 170973
  • NSC 615296
  • R 1625
Technical Information
Formal Name
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
CAS Number
52-86-8
Molecular Formula
C21H23ClFNO2
Formula Weight
375.9
Formulation
A 1 mg/ml solution in methanol
SMILES
OC1(C2=CC=C(C=C2)Cl)CCN(CC1)CCCC(C3=CC=C(C=C3)F)=O
InChi Code
InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
InChi Key
LNEPOXFFQSENCJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $38

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    Product Description

    Haloperidol (CRM) (Item No. 40431) is a certified reference material categorized as a typical antipsychotic.1 Haloperidol inhibits stereotypic behavior induced by apomorphine or amphetamine in rats.2 It also inhibits apomorphine-induced decreases in prepulse inhibition of the acoustic startle response in rats.1 Haloperidol has antinociceptive activity in mice.3 It increases error rates and reduces response rate in pigeons following learned acquisition.4 Formulations containing haloperidol have been used in the treatment of schizophrenia and Tourette syndrome. This product is intended for analytical forensic applications. This product is also available as a general research tool (Item No. 12014).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Swerdlow, N.R., and Geyer, M.A. Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol. Biochem. Behav. 44(3), 741-744 (1993).

    2. Creese, I., Burt, D.R., and Snyder, S.H. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. J. Neuropsychiatry Clin. Neurosci. 8(2), 223-226 (1996).

    3. Entrena, J.M., Cobos, E.J., Nieto, F.R., et al. Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: Role of sigma-1 receptors. Psychopharmacology (Berl.) 205(1), 21-33 (2008).

    4. Poling, A., Cleary, J., Berens, K., et al. Neuroleptics and learning: Effects of haloperidol, molindone, mesoridazine and thioridazine on the behavior of pigeons under a repeated acquisition procedure. J. Pharmacol. Exp. Ther. 255(3), 1240-1245 (1990).