A 5-HT1A partial agonist
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Active Metabolite(s)
340912-(1-Piperazinyl)pyrimidine
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Tandospirone

Item No. 40436

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3aR,4S,7R,7aS)-rel-hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione
CAS Number
87760-53-0
Synonyms
  • SM-3997
Molecular Formula
C21H29N5O2
Formula Weight
383.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1[C@]2([H])[C@@](C(N1CCCCN3CCN(C4=NC=CC=N4)CC3)=O)([H])[C@]5([H])C[C@@]2([H])CC5
InChi Code
InChI=1S/C21H29N5O2/c27-19-17-15-4-5-16(14-15)18(17)20(28)26(19)9-2-1-8-24-10-12-25(13-11-24)21-22-6-3-7-23-21/h3,6-7,15-18H,1-2,4-5,8-14H2/t15-,16+,17+,18-
InChi Key
CEIJFEGBUDEYSX-FZDBZEDMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Tandospirone is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A.1 It selectively binds to 5-HT1A receptors (Ki = 0.027 µM) over 5-HT2, 5-HT1B, 5-HT1C, and 5-HT1D receptors (Kis = 1.3, >100, 2.6, and >100 µM, respectively), as well as α1-adrenergic receptors (α1-ARs), α2-ARs, β-ARs, and dopamine D1 and D2 receptors (Kis = 1.6, 1.9, >100, 1.7, and 41 µM, respectively). Tandospirone (0.1-100 µM) reduces forskolin-induced adenylate cyclase activity in rat hippocampal homogenates. In vivo, tandospirone (10 and 20 mg/kg) reduces immobility time in the forced swim test in mice.2 Tandospirone (10 mg/kg) increases food intake and overall survival, as well as decreases body weight loss in a Yoshida hepatoma rat model of cancer cachexia.3 Formulations containing tandospirone have been used in the treatment of depression.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamik, A., Oksenberg, D., Fischette, C., et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol. Psychiatry. 28(2), 99-109 (1990).

    2. Wieland, S., and Lucki, I. Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test. Psychopharmacology (Berl.) 101(4), 497-504 (1990).

    3. Elkina, Y., Palus, S., Tschirner, A., et al. Tandospirone reduces wasting and improves cardiac function in experimental cancer cachexia. Int. J. Cardiol. 170(2), 160-166 (2013).