A nucleoside
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Product Categories

Product Type

Biochemicals
Nucleotides/Nucleosides

Research Area

Endocrinology & Metabolism

2'-O-(2-Methoxyethyl)guanosine

Item No. 40444

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one
CAS Number
473278-54-5
Molecular Formula
C13H19N5O6
Formula Weight
341.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/mlWater: Slightly Soluble: 0.1-1 mg/ml
SMILES
COCCO[C@H]1[C@H](N2C3=C(C(N=C(N)N3)=O)N=C2)O[C@@H]([C@H]1O)CO
InChi Code
InChI=1S/C13H19N5O6/c1-22-2-3-23-9-8(20)6(4-19)24-12(9)18-5-15-7-10(18)16-13(14)17-11(7)21/h5-6,8-9,12,19-20H,2-4H2,1H3,(H3,14,16,17,21)/t6-,8-,9-,12-/m1/s1
InChi Key
DLLBJSLIKOKFHE-WOUKDFQISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $28

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    250 mg

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    500 mg

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    1 g

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    Product Description

    2’-O-(2-Methoxyethyl)guanosine is a nucleoside and derivative of the purine nucleoside guanosine (Item No. 27702). Enzymes in the nucleotide salvage pathway, including deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1), exhibit poor reactivity towards 2’-O-(2-methoxyethyl)guanosine, reducing the likelihood of 2’-O-(2-methoxyethyl)guanosine conversion to its monophosphate form and incorporation into cellular RNA or DNA.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Saleh, A.F., Bachman, M., Priestley, C.C., et al. 2'-O-(2-Methoxyethyl) nucleosides are not phosphorylated or incorporated into the genome of human lymphoblastoid TK6 cells. Toxicol. Sci. 163(1), 70-78 (2018).