An internal standard for the quantification of acetyl-coenzyme A
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Acetyl-Coenzyme A-d3 (sodium salt)

Item No. 40458

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-(acetate-d3) coenzyme A, sodium salt
Synonyms
  • Acetyl-CoA-d3
Molecular Formula
C23H35D3N7O17P3S • XNa
Formula Weight
812.6
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleWater: Soluble
SMILES
O[C@H]1[C@@H](O[C@@H]([C@H]1OP(O)(O)=O)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C([2H])([2H])[2H])=O)=O)=O)(O)=O)(O)=O)N2C3=NC=NC(N)=C3N=C2.[Na]
InChi Code
InChI=1S/C23H38N7O17P3S.Na/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);/t13-,16-,17-,18+,22-;/m1./s1/i1D3;
InChi Key
XGCDESRMLMCTPI-KUULWMSYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $109

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    5 mg

    $491

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    Product Description

    Acetyl-coenzyme A-d3 (acetyl-CoA-d3) is intended for use as an internal standard for the quantification of acetyl-CoA (Item No. 16160) by GC- or LC-MS. Acetyl-CoA, the thioester of CoA (Item Nos. 16147 | 21499 | 21722) and acetic acid, is a pivotal molecule in biological systems. Foremost, it serves as a source of carbon for the Krebs cycle, for the synthesis of fatty acids, and for isoprenoid-based protein modifications.1,2,3,4 Acetyl-CoA also serves as an intermediate in oxidation of fatty acids and amino acids and is formed by the oxidative decarboxylation of pyruvate in mitochondria.5 It is an essential cofactor or substrate for acetyltransferases and acyltransferases, as in the post-translational modification of proteins and in the synthesis of the neurotransmitter acetylcholine.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akram, M. Citric acid cycle and role of its intermediates in metabolism. Cell Biochem. Biophys. 68(3), 475-478 (2014).

    2. Salminen, A., Kauppinen, A., Hiltunen, M., et al. Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process. Ageing Res. Rev. 16C, 45-65 (2014).

    3. Zaidi, N., Swinnen, J.V., and Smans, K. ATP-citrate lyase: A key player in cancer metabolism. Cancer Res. 72(15), 3709-3714 (2012).

    4. Palsson-McDermott, E.M., and O'Neill, L.A. The Warburg effect then and now: From cancer to inflammatory diseases. BioEssays 35(11), 965-973 (2013).

    5. Miura, Y. The biological significance of ω-oxidation of fatty acids. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 89(8), 370-382 (2013).