A GPX4 inhibitor
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GPX4 16

Item No. 40498

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(2E)-3-[2-(2-formylphenoxy)phenyl]-1-oxo-2-propen-1-yl]-benzonitrile
CAS Number
2644044-43-7
Synonyms
  • Glutathione Peroxidase 4 16
Molecular Formula
C23H15NO3
Formula Weight
353.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC=C(C#N)C=C1)/C=C/C2=CC=CC=C2OC3=CC=CC=C3C=O
InChi Code
InChI=1S/C23H15NO3/c24-15-17-9-11-18(12-10-17)21(26)14-13-19-5-1-3-7-22(19)27-23-8-4-2-6-20(23)16-25/h1-14,16H/b14-13+
InChi Key
UNQJNKUGIZRZER-BUHFOSPRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $74

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    5 mg

    $314

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    10 mg

    $590

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    Cayman Chemical
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    Product Description

    GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4).1 It inhibits the proliferation of Nthy-ori-3-1 transformed human thyroid follicular epithelial cells (IC50 = 8.39 µM), as well as MDA-T32 and MDA-T41 human thyroid cancer cells (IC50s = 10.29 and 8.18 µM, respectively). GPX4 16 (10 µM) induces ferroptosis in MDA-T32 cells, an effect that can be prevented by the ferroptosis inhibitor ferrostatin-1 (Item No. 17729). It reduces GPX4 protein levels in MDA-T32 cells when used at a concentration of 0.3 µM. GPX4 16 also induces the production of reactive oxygen species (ROS) and reduces glutathione (GSH) levels, mitochondrial polarization, and mitochondrial respiration in MDA-T32 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pamarthy, D., Behera, S.K., Swain, S., et al. Diaryl ether derivative inhibits GPX4 expression levels to induce ferroptosis in thyroid cancer cells. Drug Dev. Res. 84(5), 861-887 (2023).