A histamine H1 receptor antagonist
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Dimethindene (maleate)

Item No. 40649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine, 2Z-butenedioate
CAS Number
3614-69-5
Synonyms
  • Dimetindene
  • NSC 107677
  • SU 6518
Molecular Formula
C20H24N2 • C4H4O4
Formula Weight
408.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlMethanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(O)/C=C\C(O)=O.CC(C1=CC=CC=N1)C2=C(CCN(C)C)CC3=CC=CC=C23
InChi Code
InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
SWECWXGUJQLXJF-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Product Description

    Dimethindene is a histamine H1 receptor antagonist (Ki = 1.5 nM).1 It is selective for histamine H1 receptors over M1 muscarinic acetylcholine receptors (mAChRs) and the serotonin (5-HT) receptor subtype 5-HT2A (Kis = 64 and 2,400 nM, respectively). In vivo, dimethindene (0.1 mg/kg), alone or in combination with the osmotic agent icodextrin, decreases adhesions between the abdominal wall and intraperitoneal viscera and local vascularization following surgery-induced abdominal trauma in rabbits.2 Formulations containing dimethindene have been used in the treatment of dermatosis, pruritis, and nasal allergies.

    WARNING This product is not for human or veterinary use.