A histamine H1 receptor antagonist
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Dimethindene (maleate)

Item No. 40649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-3-[1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine, 2Z-butenedioate
CAS Number
3614-69-5
Synonyms
  • Dimetindene
  • NSC 107677
  • SU 6518
Molecular Formula
C20H24N2 • C4H4O4
Formula Weight
408.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlMethanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(O)/C=C\C(O)=O.CC(C1=CC=CC=N1)C2=C(CCN(C)C)CC3=CC=CC=C23
InChi Code
InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChi Key
SWECWXGUJQLXJF-BTJKTKAUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $87

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    10 mg

    $165

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    25 mg

    $392

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    100 mg

    $609

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    Product Description

    Dimethindene is a histamine H1 receptor antagonist (Ki = 1.5 nM).1 It is selective for histamine H1 receptors over M1 muscarinic acetylcholine receptors (mAChRs) and the serotonin (5-HT) receptor subtype 5-HT2A (Kis = 64 and 2,400 nM, respectively). In vivo, dimethindene (0.1 mg/kg), alone or in combination with the osmotic agent icodextrin, decreases adhesions between the abdominal wall and intraperitoneal viscera and local vascularization following surgery-induced abdominal trauma in rabbits.2 Formulations containing dimethindene have been used in the treatment of dermatosis, pruritis, and nasal allergies.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sautel, M., Towart, R., Théraulaz-Lacroix, M., et al. Effects of dimethindene maleate (Fenistil®) on histaminic, muscarinic and serotoninergic receptor systems. Agents Actions 36, C428–C430 (1992).

    2. Tepetes, K., Asprodini, E.K., Christodoulidis, G., et al. Prevention of postoperative adhesion formation by individual and combined administration of 4 per cent icodextrin and dimetindene maleate. Br. J. Surg. 96(12), 1476-1483 (2009).