An Analytical Reference Standard
Related Products
Alternative(s)
17965Lorazepam-13C2-d4 18731Lorazepam-13C2-d4 (CRM)
Certified Reference Material(s)
18728Lorazepam-d4 (CRM)
Unlabeled Version(s)
15891Lorazepam ISO60202Lorazepam (CRM)
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Lorazepam-d4

Item No. 40658

Restricted Product (Schedule IV)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Apo-Lorazepam-d4
Technical Information
Formal Name
7-chloro-5-(6-chlorophenyl-2,3,4,5-d4)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
CAS Number
84344-15-0
Molecular Formula
C15H6Cl2D4N2O2
Formula Weight
325.2
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
ClC1=C([2H])C([2H])=C([2H])C([2H])=C1C(C(C=C(Cl)C=C2)=C2N3)=NC(O)C3=O
InChi Code
InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)/i1D,2D,3D,4D
InChi Key
DIWRORZWFLOCLC-RHQRLBAQSA-N
Regulatory Information
DEA Schedule
IV
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $146

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    Product Description

    Lorazepam-d4 (Item No. 40658) is intended for use as an internal standard for the quantification of lorazepam (Item Nos. ISO60202 | 15891) by GC- or LC-MS. Lorazepam is categorized as a benzodiazepine.1,2 It has anxiolytic properties and is a metabolite of diclazepam (Item Nos. 28623 | 15554).2,3 Formulations containing lorazepam have been used in the treatment of anxiety. Lorazepam-d4 is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miller, L.G., Greenblatt, D.J., Barnhill, J.G., et al. Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine receptor downregulation and decreased γ-aminobutyric acidA receptor function. J. Pharmacol. Exp. Ther. 246(1), 170-176 (1988).

    2. Baldwin, D., Woods, R., Lawson, R., et al. Efficacy of drug treatments for generalised anxiety disorder: Systematic review and meta-analysis. BMJ 342, d1199 (2011).

    3. Moosmann, B., Bisel, P., and Auwärter, V. Characterization of the designer benzodiazepine diclazepam and preliminary data on its metabolism and pharmacokinetics. Drug Test Anal. 6(7-8), 757-763 (2014).