A saponin with diverse biological activities
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Isomer(s)
29455Pulsatilla Saponin D
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Soyasaponin II

Item No. 40661

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,4β,22β)-22,23-dihydroxyolean-12-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-α-L-arabinopyranosyl-(1→2)-β-D-glucopyranosiduronic acid
CAS Number
55319-36-3
Synonyms
  • Soyasaponin Bc
  • Soyasaponin BII
Molecular Formula
C47H76O17
Formula Weight
913.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/mlMethanol: Slightly soluble: 0.1-1 mg/mlWater: Sparingly soluble: 1-10 mg/ml
SMILES
C[C@@]1(CC[C@@]2([H])[C@]3(CO)C)[C@@](CC=C([C@]4([H])CC(C)(C)C[C@H]5O)[C@]1(CC[C@]45C)C)([H])[C@]2(CC[C@@H]3O[C@H](O[C@@H]6C(O)=O)[C@@H]([C@H]([C@@H]6O)O)O[C@H](OC[C@@H]7O)[C@@H]([C@H]7O)O[C@H](O[C@H]8C)[C@@H]([C@@H]([C@H]8O)O)O)C
InChi Code
InChI=1S/C47H76O17/c1-21-29(51)31(53)34(56)39(60-21)63-36-30(52)24(49)19-59-40(36)64-37-33(55)32(54)35(38(57)58)62-41(37)61-28-12-13-44(5)25(45(28,6)20-48)11-14-47(8)26(44)10-9-22-23-17-42(2,3)18-27(50)43(23,4)15-16-46(22,47)7/h9,21,23-37,39-41,48-56H,10-20H2,1-8H3,(H,57,58)/t21-,23-,24-,25+,26+,27+,28-,29-,30-,31+,32-,33-,34+,35-,36+,37+,39-,40-,41+,43+,44-,45+,46+,47+/m0/s1
InChi Key
IBZLICPLPYSFNZ-IVWMTKFPSA-N
Origin
Plant/Sophora moorcroftiana
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Soyasaponin II is a saponin that has been found in soybeans and has diverse biological activities.1,2,3 It inhibits the proliferation of, and induces apoptosis in, HeLa cells when used at concentrations ranging from 100 to 400 mg/L.1 It inhibits viral replication in cells infected with herpes simplex virus 1 (HSV-1), human cytomegalovirus (HCMV), or influenza virus (IC50s = 54, 104, and 88 µM, respectively).2 In vivo, soyasaponin II (5 mg/kg) prevents the development of acute liver failure in a mouse model of LPS/D-galactosamine-induced acute liver injury.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiao, J.-X., Huang, G.-Q., and Zhang, S.-H. Soyasaponins inhibit the proliferation of Hela cells by inducing apoptosis. Exp. Toxicol. Pathol. 59(1), 35-42 (2007).

    2. Hayashi, K., Hayashi, H., Hiraoka, N., et al. Inhibitory activity of soyasaponin II on virus replication in vitro. Planta Med. 63(2), 102-105 (1997).

    3. Wang, F., Gong, S., Wang, T., et al. Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice. Theranostics 10(6), 2714-2726 (2020).