A nucleoside derivative and an active metabolite of sapacitabine
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Pro-drug Form(s)
27321Sapacitabine
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CNDAC (hydrochloride)

Item No. 40672

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-1-(2-cyano-2-deoxy-β-D-arabinofuranosyl)-2(1H)-pyrimidinone, monohydrochloride
CAS Number
134665-72-8
Molecular Formula
C10H12N4O4 • HCl
Formula Weight
288.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
OC[C@@H]1[C@@H](O)[C@H](C#N)[C@H](N2C(N=C(N)C=C2)=O)O1.Cl
InChi Code
InChI=1S/C10H12N4O4.ClH/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17;/h1-2,5-6,8-9,15-16H,4H2,(H2,12,13,17);1H/t5-,6+,8-,9+;/m0./s1
InChi Key
PKGUOXDXRLGZBN-KUAPJGQRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    CNDAC is a nucleoside derivative and an active metabolite of the prodrug sapacitabine.1 It induces chromosomal aberrations in UV41 cells lacking DNA repair endonuclease XPF when used at a concentration of 1 µM. CNDAC is cytotoxic to BRCA1-/- UWB1.289 and BRCA2-/- PEO1 ovarian cancer cells (IC50s = 9.9 and 10.2 nM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, X., Jiang, Y., Takata, K.I., et al. CNDAC-induced DNA double-strand breaks cause aberrant mitosis prior to cell death. Mol. Cancer Ther. 18(12), 2283-2295 (2019).

    2. Liu, X., Jiang, Y., Nowak, B., et al. Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations. Cancer Chemother. Pharmacol. 81(2), 255-267 (2018).