A transformation product of 6-PPD
Related Products
Parent Compound(s)
24250Diphenylamine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

4-Hydroxydiphenylamine

Item No. 40730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(phenylamino)-phenol
CAS Number
122-37-2
Synonyms
  • 4-HDPA
  • p-Hydroxydiphenylamine
  • para-Hydroxydiphenylamine
  • NSC 1543
Molecular Formula
C12H11NO
Formula Weight
185.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
OC1=CC=C(NC2=CC=CC=C2)C=C1
InChi Code
InChI=1S/C12H11NO/c14-12-8-6-11(7-9-12)13-10-4-2-1-3-5-10/h1-9,13-14H
InChi Key
JTTMYKSFKOOQLP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 g

    $64

    Add

    50 g

    $121

    Add

    100 g

    $230

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    4-Hydroxydiphenylamine (4-HDPA) is an aqueous transformation product of the substituted p-phenylenediamine and antiozonant 6-PPD (Item No. 38246).1 It is also a biotransformation product of 6-PPD in zebrafish embryos and an active metabolite of the antioxidant and pesticide diphenylamine (Item No. 24250).2,3 4-HDPA scavenges carbon radicals in an AIBN-induced methyl methacrylate polymerization assay in a concentration-dependent manner.4 It has been found in tire wear particles, roadway runoff, and roadway-impacted creeks.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, H.N., Hu, X., Tian, Z., et al. Transformation products of tire rubber antioxidant 6PPD in heterogeneous gas-phase ozonation: Identification and environmental occurrence. Environ. Sci. Technol. 57(14), 5621-5632 (2023).

    2. Grasse, N., Seiwert, B., Massei, R., et al. Uptake and biotransformation of the tire rubber-derived contaminants 6-PPD and 6-PPD quinone in the zebrafish embryo (Danio rerio). Environ. Sci. Technol. 57(41), 15598-15607 (2023).

    3. Alexander, W.E., Ryan, A.J., and Wright, S.E. Metabolism of diphenylamine in the rat, rabbit and man. Food Cosmet. Toxicol. 3(4), 571-579 (1965).

    4. Fujisawa, S., Ishihara, M., and Kadoma, Y. Antioxidant activity of diphenylamine–related compounds as scavengers of carbon radicals. J. Mol. Des. 4, 711-720 (2005).