A derivative of cytidine
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5-Hydroxymethylcytidine

Item No. 40745

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(hydroxymethyl)-cytidine
CAS Number
19235-17-7
Synonyms
  • 5-hmrC
  • hm5C
Molecular Formula
C10H15N3O6
Formula Weight
273.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
NC(C(CO)=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=NC1=O
InChi Code
InChI=1S/C10H15N3O6/c11-8-4(2-14)1-13(10(18)12-8)9-7(17)6(16)5(3-15)19-9/h1,5-7,9,14-17H,2-3H2,(H2,11,12,18)/t5-,6-,7-,9-/m1/s1
InChi Key
NFEXJLMYXXIWPI-JXOAFFINSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $64

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    10 mg

    $109

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    25 mg

    $256

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    50 mg

    $479

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    Product Description

    5-Hydroxymethylcytidine is a derivative of the pyrimidine nucleoside cytidine (Item No. 29602).1 It can be formed in RNA via the oxidation of 5-methylcytidine by ten-eleven translocation (TET) enzymes but can also be formed via non-TET mechanisms.2,1 5-Hydroxymethylcytidine has been found as an RNA modification in Archaea, bacteria, and eukaryotes.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huber, S.M., van Delft, P., Mendil, L., et al. Formation and abundance of 5-hydroxymethylcytosine in RNA. Chembiochem 16(5), 752-755 (2015).

    2. Fu, L., Guerrero, C.R., Zhong, N., et al. Tet-mediated formation of 5-hydroxymethylcytosine in RNA. J. Am. Chem. Soc. 136(33), 11582-11585 (2014).