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Cytidine is a pyrimidine nucleoside composed of ribose and a cytosine base.1 It forms complementary base pairs with the purine nucleoside guanosine (Item No. 27702) in DNA and RNA. Cytidine is a precursor of uridine (Item No. 20300) and can also be phosphorylated by uridine-cytidine kinase to form CMP (Item No. 35116).2,1 It rescues inhibition of proliferation induced by knockdown of CTP synthase 1 in T cells when used at a concentration of 200 µM.3
WARNING This product is not for human or veterinary use.
1. Nucleotide biosynthesis. Biochemistry (2002).
2. Purification and properties of cytidine deaminase from normal and leukemic granulocytes. J. Clin. Invest. 53(3), 922-931 (1974).
3. CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation. Nature 510(7504), 288-292 (2014).