A synthetic intermediate
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Semaglutide Side Chain

Item No. 40746

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
22S-[(1,1-dimethylethoxy)carbonyl]-10,19,24-trioxo-3,6,12,15-Tetraoxa-9,18,23-triazahentetracontanedioic acid, 41-(1,1-dimethylethyl) ester
CAS Number
1118767-16-0
Molecular Formula
C43H79N3O13
Formula Weight
846.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(O)COCCOCCNC(COCCOCCNC(CC[C@@H](C(OC(C)(C)C)=O)NC(CCCCCCCCCCCCCCCCC(OC(C)(C)C)=O)=O)=O)=O
InChi Code
InChI=1S/C43H79N3O13/c1-42(2,3)58-40(52)22-20-18-16-14-12-10-8-7-9-11-13-15-17-19-21-37(48)46-35(41(53)59-43(4,5)6)23-24-36(47)44-25-27-54-29-31-56-33-38(49)45-26-28-55-30-32-57-34-39(50)51/h35H,7-34H2,1-6H3,(H,44,47)(H,45,49)(H,46,48)(H,50,51)/t35-/m0/s1
InChi Key
YZUXNRZPWYRMGH-DHUJRADRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $109

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    1 g

    $196

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    Cayman Chemical
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    Product Description

    Semaglutide side chain is a synthetic intermediate.1 It has been used as an intermediate in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide (Item Nos. 40231 | 29969 | 40170), as well as a lipid side chain to increase the proteolysis-resistance of insulin derivatives for use in vivo.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guryanov, I., Orlandin, A., De Paola, I., et al. Copper(II) lysinate and pseudoproline assistance in the convergent synthesis of the GLP 1 receptor agonists liraglutide and semaglutide. Org. Process Res. Dev. 25(7), 1598-1611 (2021).

    2. Kjeldsen, T.B., Hubálek, F., Tagmose, T.M., et al. Engineering of orally available, ultralong-acting insulin analogues: Discovery of OI338 and OI320. J. Med. Chem. 64(1), 616-628 (2021).