A synthetic coumarin
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Coumarin 478

Item No. 40754

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,6,7,10,11-hexahydro-1H,5H-cyclopenta[3,4][1]benzopyrano[6,7,8-ij]quinolizin-12(9H)-one
CAS Number
41175-45-5
Synonyms
  • Coumarin 106
  • NSC 290434
Molecular Formula
C18H19NO2
Formula Weight
281.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1OC2=C(C3=C1CCC3)C=C4C5=C2CCCN5CCC4
InChi Code
InChI=1S/C18H19NO2/c20-18-13-6-1-5-12(13)15-10-11-4-2-8-19-9-3-7-14(16(11)19)17(15)21-18/h10H,1-9H2
InChi Key
LLSRPENMALNOFW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $72

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    100 mg

    $137

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    250 mg

    $323

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    Product Description

    Coumarin 478 is a synthetic coumarin.1 It is an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE; IC50s = 10.7 and 27.8 µM, respectively). Coumarin 478 displays absorption/emission maxima of 386/478 nm, respectively.2 It also displays a phosphorescence maximum of approximately 530 nm when applied to polyvinyl alcohol films and excited at 365 nm.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fallarero, A., Oinonen, P., Gupta, S., et al. Inhibition of acetylcholinesterase by coumarins: The case of coumarin 106. Pharmacol. Res. 58(3-4), 215-221 (2008).

    2. Reynolds, G.A., and Drexhage, K.H. New coumarin dyes with rigidized structure for flashlamp-pumped dye lasers. Opt. Commun. 13(3), 222-225 (1975).

    3. Alexander, E., Chavez, J., Ceresa, L., et al. Room temperature phosphorescence of coumarin 106 with direct triplet state excitation. Dyes Pigments 217, 111389 (2023).