An inhibitor of ROCK1 and ROCK2 and an active metabolite of HA-1077
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Parent Compound(s)
10010559HA-1077 (hydrochloride)
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Hydroxyfasudil

Item No. 40814

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-1(2H)-isoquinolinone
CAS Number
105628-72-6
Molecular Formula
C14H17N3O3S
Formula Weight
307.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1NC=CC2=C(S(=O)(N3CCCNCC3)=O)C=CC=C21
InChi Code
InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)
InChi Key
ZAVGJDAFCZAWSZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $65

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    10 mg

    $110

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    25 mg

    $228

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    50 mg

    $325

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Hydroxyfasudil is an inhibitor of ROCK1 and ROCK2 (IC50s = 0.15 and 0.57 µM, respectively) and an active metabolite of the Rho-associated kinase (ROCK) inhibitor HA-1077 (fasudil; Item No. 10010559).1 In vivo, hydroxyfasudil (3 and 10 mg/kg) decreases blood viscosity and prevents cerebral vasospasm in a canine model of subarachnoid hemorrhage.2 Hydroxyfasudil also reverses hypertension-associated dysfunction of relaxation induced by nitric oxide in corpus cavernosum smooth muscle in spontaneously hypertensive rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zaky, Y.A., Rashad, M.W., Zaater, M.A., et al. Discovery of dual rho-associated protein kinase 1 (ROCK1)/apoptosis signal-regulating kinase 1 (ASK1) inhibitors as a novel approach for non-alcoholic steatohepatitis (NASH) treatment. BMC Chem. 18(1), 2 (2024).

    2. Satoh, S., Takayasu, M., Kawasaki, K., et al. Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage. J. Pharmacol. Sci. 118(1), 92-98 (2012).

    3. Saito, M., Ohmasa, F., Dimitriadis, F., et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol. Res. 66(4), 325-331 (2012).