A glycoside with diverse biological activities
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Ziyuglycoside II

Item No. 40831

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-(α-L-arabinopyranosyloxy)-19-hydroxy-urs-12-en-28-oic acid
CAS Number
35286-59-0
Synonyms
  • ZGS II
Molecular Formula
C35H56O8
Formula Weight
604.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
OC([C@]12[C@]([C@](O)([C@@H](CC2)C)C)([H])C3=CC[C@@]([C@@]4([C@@](C(C)([C@H](CC4)O[C@H]5[C@@H]([C@H]([C@H](CO5)O)O)O)C)([H])CC6)C)([H])[C@]6(C)[C@@]3(CC1)C)=O
InChi Code
InChI=1S/C35H56O8/c1-19-10-15-35(29(39)40)17-16-32(5)20(27(35)34(19,7)41)8-9-23-31(4)13-12-24(30(2,3)22(31)11-14-33(23,32)6)43-28-26(38)25(37)21(36)18-42-28/h8,19,21-28,36-38,41H,9-18H2,1-7H3,(H,39,40)/t19-,21+,22+,23-,24+,25+,26-,27-,28+,31+,32-,33-,34-,35+/m1/s1
InChi Key
MFIXLWYJTVEVGO-YHGWSDCJSA-N
Origin
Plant/Sanguisorba officinalis L.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $103

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    25 mg

    $229

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    50 mg

    $405

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    Cayman Chemical
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    Product Description

    Ziyuglycoside II is a steroid glycoside that has been found in S. officinalis and has diverse biological activities.1,2,3 It is cytotoxic to SMMC-7721, PC-9, HCT116, MCF-7, and MDA-MB-231 cancer cells when used at concentrations of 30 and 90 µg/ml.1 Ziyuglycoside II (6, 12, and 18 mg/kg) increases the number of white blood cells in peripheral blood and the number of hematopoietic stem and progenitor cells (HSPCs) in a mouse model of leukopenia induced by the nitrogen mustard alkylating agent cyclophosphamide (Item No. 13849).2 It also reduces small intestinal epithelial cell apoptosis and IL-1β, IL-6, and TNF-α levels, as well as improves diarrhea symptoms in a mouse model of rotavirus-induced diarrhea.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liao, W., Fan, L., Zheng, Z., et al. Ziyuglycoside II exerts antiproliferative and antimetastasis effects on hepatocellular carcinoma cells. Anticancer Drugs 31(8), 819-827 (2020).

    2. Fang, H., Xie, X., Liu, P., et al. Ziyuglycoside II alleviates cyclophosphamide-induced leukopenia in mice via regulation of HSPC proliferation and differentiation. Biomed. Pharmacother. 132:110862, (2020).

    3. Chen, X., Liu, L., Chen, W., et al. Ziyuglycoside II inhibits rotavirus induced diarrhea possibly via TLR4/NF-κB pathways. Biol. Pharm. Bull. 43(6), 932-937 (2020).