An ionizable cationic lipid
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C9-200

Item No. 40862

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1'-((2-(4-(2-((2-(bis(2-hydroxynonyl)amino)ethyl)(2-hydroxynonyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(nonan-2-ol)
Molecular Formula
C55H115N5O5
Formula Weight
926.5
Purity
≥95% (mixture of isomers)
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/ml
SMILES
OC(CCCCCCC)CN(CCN(CC(CCCCCCC)O)CC(CCCCCCC)O)CCN1CCN(CCN(CC(CCCCCCC)O)CC(CCCCCCC)O)CC1
InChi Code
InChI=1S/C55H115N5O5/c1-6-11-16-21-26-31-51(61)46-58(43-45-60(49-54(64)34-29-24-19-14-9-4)50-55(65)35-30-25-20-15-10-5)42-40-56-36-38-57(39-37-56)41-44-59(47-52(62)32-27-22-17-12-7-2)48-53(63)33-28-23-18-13-8-3/h51-55,61-65H,6-50H2,1-5H3
InChi Key
RLGMOTIOGPJNJN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $35

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    5 mg

    $120

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    10 mg

    $205

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    25 mg

    $427

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    Cayman Chemical
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    Product Description

    C9-200 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNPs).1 LNPs containing C9-200 and encapsulating mRNA encoding erythropoietin (EPO) increase serum EPO levels in mice. LNPs containing C9-200 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR) induce 3-fold higher hepatic insertion and deletion (indel) formation than LNPs containing C12-200 (Item No. 36699) and encapsulating mRNA encoding Cas9 in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mrksich, K., Padilla, M.S., Joseph, R.A., et al. Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. J. Biomed. Mater. Res. A 112(9), 1494-1505 (2024).