A branched-chain ionizable cationic lipidoid
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C12-200

Item No. 36699

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1′-[[2-[4-[2-[[2-[bis(2-hydroxydodecyl)amino]ethyl](2-hydroxydodecyl)amino]ethyl]-1-piperazinyl]ethyl]imino]bis-2-dodecanol
CAS Number
1220890-25-4
Molecular Formula
C70H145N5O5
Formula Weight
1136.9
Purity
≥95%
Formulation (Request formulation change)
A 100 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble
SMILES
OC(CCCCCCCCCC)CN(CCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)CCN1CCN(CCN(CC(CCCCCCCCCC)O)CC(CCCCCCCCCC)O)CC1
InChi Code
InChI=1S/C70H145N5O5/c1-6-11-16-21-26-31-36-41-46-66(76)61-73(58-60-75(64-69(79)49-44-39-34-29-24-19-14-9-4)65-70(80)50-45-40-35-30-25-20-15-10-5)57-55-71-51-53-72(54-52-71)56-59-74(62-67(77)47-42-37-32-27-22-17-12-7-2)63-68(78)48-43-38-33-28-23-18-13-8-3/h66-70,76-80H,6-65H2,1-5H3
InChi Key
RVHYPUORVDKRTM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $120

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    25 mg

    $240

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    50 mg

    $421

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    100 mg

    $780

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    Product Description

    C12-200 is a branched-chain ionizable cationic lipidoid.1,2 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, or self-amplifying RNA (saRNA). LNPs containing C12-200 and encapsulating an mRNA reporter selectively accumulate in the liver, and to a lesser extent in the spleen and pancreas, in mice.1 Administration of human erythropoietin (EPO) mRNA or factor VII siRNA in C12-200-containing LNPs increases serum EPO levels and reduces factor VII serum levels, respectively, in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kauffman, K.J., Dorkin, J.R., Yang, J.H., et al. Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs. Nano Lett. 15(11), 7300-7306 (2015).

    2. Blakney, A.K., McKay, P.F., Yus, B.I., et al. Inside out: Optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA. Gene Ther. 26(9), 363-372 (2019).