An ionizable cationic lipid
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C10-200

Item No. 40863

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1'-((2-(4-(2-((2-(bis(2-hydroxydecyl)amino)ethyl)(2-hydroxydecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(decan-2-ol)
CAS Number
3082233-50-6
Molecular Formula
C60H125N5O5
Formula Weight
996.7
Purity
≥95% (mixture of isomers)
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/mL
SMILES
OC(CCCCCCCC)CN(CCN(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CCN1CCN(CCN(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CC1
InChi Code
InChI=1S/C60H125N5O5/c1-6-11-16-21-26-31-36-56(66)51-63(48-50-65(54-59(69)39-34-29-24-19-14-9-4)55-60(70)40-35-30-25-20-15-10-5)47-45-61-41-43-62(44-42-61)46-49-64(52-57(67)37-32-27-22-17-12-7-2)53-58(68)38-33-28-23-18-13-8-3/h56-60,66-70H,6-55H2,1-5H3
InChi Key
BLPKMPWPNQWRQP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $81

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    10 mg

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    25 mg

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    50 mg

    $482

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    Product Description

    C10-200 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing C10-200 and encapsulating mRNA encoding a luciferase reporter selectively induce luminescence in the livers of mice to a greater extent than LNPs containing the branched-chain ionizable cationic lipidoid C12-200 (Item No. 36699). LNPs containing C10-200 and encapsulating mRNA encoding erythropoietin (EPO) increase serum levels of EPO in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mrksich, K., Padilla, M.S., Joseph, R.A., et al. Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. J. Biomed. Mater. Res. A 112(9), 1494-1505 (2024).