A microbial metabolite with diverse biological activities
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Cladosporin

Item No. 40864

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R)-3,4-dihydro-6,8-dihydroxy-3-[[(2R,6S)-tetrahydro-6-methyl-2H-pyran-2-yl]methyl]-1H-2-benzopyran-1-one
CAS Number
35818-31-6
Synonyms
  • Asperentin
Molecular Formula
C16H20O5
Formula Weight
292.3
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Dichloromethane: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
O=C1C2=C(O)C=C(O)C=C2C[C@@H](O1)C[C@@H]3O[C@H](CCC3)C
InChi Code
InChI=1S/C16H20O5/c1-9-3-2-4-12(20-9)8-13-6-10-5-11(17)7-14(18)15(10)16(19)21-13/h5,7,9,12-13,17-18H,2-4,6,8H2,1H3/t9-,12+,13+/m0/s1
InChi Key
WOMKDMUZNBFXKG-ZWKOPEQDSA-N
Origin
Bacterium/Penicillium atrovenetum
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $384

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    Product Description

    Cladosporin is a microbial metabolite originally isolated from C. cladosporiodes that has diverse biological activities.1,2,3 It selectively inhibits P. falciparum lysyl-tRNA ligase over human lysyl-tRNA ligase (IC50s = 0.061 and >20 µM, respectively).1 Cladosporin inhibits the replication of eight strains of Plasmodium with IC50 values ranging from 45.4 to 89.6 nM and decreases P. falciparum protein synthesis by 75% at 610 nM. It is active against the bacteria M. flavus (MIC = 40 µg/ml) and inhibits spore germination by the plant pathogenic fungi P. viridicatum when used at a concentration of 5 µg/ml.2 Cladosporin (30 µM) inhibits the growth of the plant pathogenic fungi C. acutatum, C. fragariae, C. gloeosporioides, and P. viticola.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoepfner, D., McNamara, C.W., Lim, C.S., et al. Selective and specific inhibition of the Plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe 11(6), 654-663 (2021).

    2. Scott, P.M., Van Walbeek, W., and MacLean, W.M. Cladosporin, a new antifungal metabolite from Cladosporium cladosporioides. J. Antibiot. (Tokyo) 24(11), 747-755 (1971).

    3. Wang, X., Radwan, M.M., Taráwneh, A.H., et al. Antifungal activity against plant pathogens of metabolites from the endophytic fungus Cladosporium cladosporioides. J. Agric. Food Chem. 61(19), 4551-4555 (2013).