A PAD4 inhibitor
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GSK199 analog (hydrochloride)

Item No. 40866

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone, monohydrochloride
CAS Number
2048226-46-4
Molecular Formula
C25H29N5O2 • HCl
Formula Weight
468.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
N[C@H]1CN(C(C2=CC(N=C(C3=CC(C=CC=C4)=C4N3CC)N5C)=C5C(OC)=C2)=O)CCC1.Cl
InChi Code
InChI=1S/C25H29N5O2.ClH/c1-4-30-20-10-6-5-8-16(20)13-21(30)24-27-19-12-17(14-22(32-3)23(19)28(24)2)25(31)29-11-7-9-18(26)15-29;/h5-6,8,10,12-14,18H,4,7,9,11,15,26H2,1-3H3;1H/t18-;/m1./s1
InChi Key
XPTWJBGBFGNEIM-GMUIIQOCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $53

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    5 mg

    $198

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    10 mg

    $291

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    25 mg

    $528

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    Product Description

    GSK199 analog is an inhibitor of peptidyl arginine deiminase 4 (PAD4) and a derivative of the PAD4 inhibitor GSK199.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Amans, D., Atkinson, S.J., Barker, M.D., et al. Benzomidazole derivatives as PAD4 inhibitors. (2016).

    Product Citations

    Pasquero, S., Gugliesi, F., Griffante, G., et al. Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2. Antiviral Res. 200, 105278 (2022).