An IRE1α inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

GSK2850163

Item No. 40917

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(3,4-dichlorophenyl)methyl]-N-[(4-methylphenyl)methyl]-2,7-diazaspiro[4.5R]decane-7-carboxamide
CAS Number
2121989-91-9
Synonyms
  • GSK163
Molecular Formula
C24H29Cl2N3O
Formula Weight
446.4
Purity
≥98%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
O=C(N1CCC[C@@]2(CN(CC3=CC(Cl)=C(Cl)C=C3)CC2)C1)NCC4=CC=C(C)C=C4
InChi Code
InChI=1S/C24H29Cl2N3O/c1-18-3-5-19(6-4-18)14-27-23(30)29-11-2-9-24(17-29)10-12-28(16-24)15-20-7-8-21(25)22(26)13-20/h3-8,13H,2,9-12,14-17H2,1H3,(H,27,30)/t24-/m1/s1
InChi Key
YFDASBFQKMHSSJ-XMMPIXPASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $83

    Add

    10 mg

    $149

    Add

    25 mg

    $310

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    GSK2850163 is an inhibitor of inositol-requiring enzyme 1α (IRE1α; IC50s = 0.2 and 0.02 µM for RNase and kinase activity, respectively).1 It is selective for IRE1α over Ron and FGFR1 (IC50s = 4.4 and 17 µM), as well as a panel of 282 kinases at 10 µM. GSK2850163 (8 µM) inhibits endoplasmic reticulum (ER) stress-induced increases in the splicing of mRNA encoding X-box binding protein 1 (XBP1) in eight multiple myeloma cell lines. It reduces viral replication in tick-borne encephalitis virus-infected SH-SY5Y and SNB-19 cells when used at a concentration of 0.5 µM or tick-borne encephalitis virus-infected Caco-2 cells at 1 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Concha, N.O., Smallwood, A., Bonnette, W., et al. Long-range inhibitor-induced conformational regulation of human IRE1α endoribonuclease activity. Mol. Pharmacol. 88(6), 1011-1023 (2015).

    2. Breitkopf, V.J.M., Dobler, G., Claus, P., et al. IRE1-Mediated unfolded protein response promotes the replication of tick-borne flaviviruses in a virus and cell-type dependent manner. Viruses 13(11), 2164 (2021).