An intermediate in the synthesis of LYTACs
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Tri-GalNAc COOH

Item No. 40934

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]-6,6-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-25-hydroxy-8-oxo-4,11,14,17,20,23-hexaoxa-7-azapentacosanamide
CAS Number
1953146-81-0
Synonyms
  • SGN-46810
Molecular Formula
C75H134N10O35
Formula Weight
1735.9
Purity
≥95%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly soluble: 1-10 mg/mlMethanol: Sparingly soluble: 1-10 mg/ml
SMILES
O[C@@H]1[C@H](O)[C@@H](NC(C)=O)[C@H](OCCCCC(NCCCNC(CCOCC(COCCC(NCCCNC(CCCCO[C@@H]2O[C@@H]([C@@H]([C@@H]([C@H]2NC(C)=O)O)O)CO)=O)=O)(COCCC(NCCCNC(CCCCO[C@@H]3O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O)O)CO)=O)=O)NC(CCOCCOCCOCCOCCOCCC(O)=O)=O)=O)=O)O[C@@H]1CO
InChi Code
InChI=1S/C75H134N10O35/c1-49(89)82-63-69(104)66(101)52(43-86)118-72(63)115-27-7-4-13-55(92)76-21-10-24-79-58(95)16-31-112-46-75(85-61(98)19-30-107-35-37-109-39-41-111-42-40-110-38-36-108-34-20-62(99)100,47-113-32-17-59(96)80-25-11-22-77-56(93)14-5-8-28-116-73-64(83-50(2)90)70(105)67(102)53(44-87)119-73)48-114-33-18-60(97)81-26-12-23-78-57(94)15-6-9-29-117-74-65(84-51(3)91)71(106)68(103)54(45-88)120-74/h52-54,63-74,86-88,101-106H,4-48H2,1-3H3,(H,76,92)(H,77,93)(H,78,94)(H,79,95)(H,80,96)(H,81,97)(H,82,89)(H,83,90)(H,84,91)(H,85,98)(H,99,100)/t52-,53-,54-,63-,64-,65-,66+,67+,68+,69-,70-,71-,72-,73-,74-/m1/s1
InChi Key
SPYOMGAJOYWUJU-JNYSMVCCSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    Product Description

    Tri-GalNAc COOH is an intermediate in the synthesis of lysosome-targeting chimeras (LYTACs) containing a triad of the galactose amino sugar derivative GalNAc (Item No. 31728) connected by acyl-amino chains to an ether linker with a terminal carboxylic acid that can be functionalized with antibodies or biotin.1 It has been used in the synthesis of LYTACs functionalized with anti-EGFR antibodies that reduce EGFR levels without affecting total protein levels in HepG2 hepatocellular carcinoma cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, Y., Teng, P., Montgomery, N.T., et al. Development of triantennary N-acetylgalactosamine conjugates as degraders for extracellular proteins. ACS Cent. Sci. 7(3), 499-506 (2021).