A synthetic peptide and dual agonist of GLP-1R and GCGR
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Mazdutide

Item No. 40971

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidyl-2-methylalanyl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-α-aspartyl-L-α-glutamyl-L-lysyl-L-lysyl-L-alanyl-N6-[N-(19-carboxy-1-oxononadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-valyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-leucyl-L-α-glutamylglycylglycyl-L-prolyl-L-seryl-L-seryl-glycinamide
CAS Number
2259884-03-0
Synonyms
  • IBI362
  • LY3305677
Molecular Formula
C210H322N46O67
Formula Weight
4563.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(N)CNC([C@H](CO)NC([C@H](CO)NC([C@H]1N(C(CNC(CNC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@H](CC4=CC=CC=C4)NC([C@H](CCC(O)=O)NC([C@H](CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@H](NC(CCCCCCCCCCCCCCCCCCC(O)=O)=O)C(O)=O)=O)=O)=O)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC7=CC=CC=C7)NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(N)=O)NC(C(C)(C)NC([C@H](CC8=CNC=N8)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O)=O
InChi Code
InChI=1S/C210H322N46O67/c1-117(2)93-145(191(300)233-139(70-76-170(276)277)181(290)224-107-164(269)222-109-168(273)256-86-46-57-159(256)204(313)249-157(112-259)203(312)247-155(110-257)183(292)223-106-161(216)266)237-192(301)146(94-118(3)4)239-196(305)152(100-128-104-221-134-52-37-36-51-132(128)134)243-190(299)143(73-79-173(282)283)236-205(314)176(120(7)8)253-199(308)150(96-124-47-30-28-31-48-124)241-189(298)142(72-78-172(280)281)234-185(294)136(56-41-45-83-218-166(271)114-322-91-90-321-88-85-220-167(272)115-323-92-89-320-87-84-219-162(267)75-69-144(208(317)318)228-163(268)58-34-26-24-22-20-18-16-14-15-17-19-21-23-25-27-35-59-169(274)275)229-179(288)121(9)227-184(293)135(53-38-42-80-211)230-186(295)137(54-39-43-81-212)231-188(297)141(71-77-171(278)279)235-197(306)153(102-174(284)285)244-193(302)147(95-119(5)6)238-194(303)148(98-126-60-64-130(263)65-61-126)240-187(296)138(55-40-44-82-213)232-201(310)156(111-258)248-195(304)149(99-127-62-66-131(264)67-63-127)242-198(307)154(103-175(286)287)245-202(311)158(113-260)250-207(316)178(123(11)262)254-200(309)151(97-125-49-32-29-33-50-125)246-206(315)177(122(10)261)252-165(270)108-225-182(291)140(68-74-160(215)265)251-209(319)210(12,13)255-180(289)133(214)101-129-105-217-116-226-129/h28-33,36-37,47-52,60-67,104-105,116-123,133,135-159,176-178,221,257-264H,14-27,34-35,38-46,53-59,68-103,106-115,211-214H2,1-13H3,(H2,215,265)(H2,216,266)(H,217,226)(H,218,271)(H,219,267)(H,220,272)(H,222,269)(H,223,292)(H,224,290)(H,225,291)(H,227,293)(H,228,268)(H,229,288)(H,230,295)(H,231,297)(H,232,310)(H,233,300)(H,234,294)(H,235,306)(H,236,314)(H,237,301)(H,238,303)(H,239,305)(H,240,296)(H,241,298)(H,242,307)(H,243,299)(H,244,302)(H,245,311)(H,246,315)(H,247,312)(H,248,304)(H,249,313)(H,250,316)(H,251,319)(H,252,270)(H,253,308)(H,254,309)(H,255,289)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,317,318)/t121-,122+,123+,133-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152
InChi Key
NCZIWZAVWHEUKM-SQZAUUIPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Mazdutide is a synthetic peptide derivative of the gut peptide hormone oxyntomodulin and a dual agonist of the glucagon-like peptide 1 receptor (GLP-1R) and glucagon receptor (GCGR).1 It reduces body weight in both Gcgr-/- and Glp1r-/- mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ji, L., Jiang, H., An, P., et al. IBI362 (LY3305677), a weekly-dose GLP-1 and glucagon receptor dual agonist, in Chinese adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose phase 1b study. EClinicalMedicine 39, 101088 (2021).