A prodrug form of omidenepag
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Active Metabolite(s)
41045Omidenepag (free acid)
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Omidenepag Isopropyl

Item No. 41046

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](3-sulfonyl)amino]methyl]-2-pyridinyl]-glycine, 1-methylethyl ester
CAS Number
1187451-19-9
Synonyms
  • DE 117
  • OMDI
Molecular Formula
C26H28N6O4S
Formula Weight
520.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=[S](N(CC1=CC=C(N2C=CC=N2)C=C1)CC3=CC=CC(NCC(OC(C)C)=O)=N3)(C4=CN=CC=C4)=O
InChi Code
InChI=1S/C26H28N6O4S/c1-20(2)36-26(33)17-28-25-8-3-6-22(30-25)19-31(37(34,35)24-7-4-13-27-16-24)18-21-9-11-23(12-10-21)32-15-5-14-29-32/h3-16,20H,17-19H2,1-2H3,(H,28,30)
InChi Key
VIQCWEGEHRBLAC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    10 mg

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    Product Description

    Omidenepag isopropyl is a prodrug form of omidenepag (Item No. 41045), a non-prostaglandin agonist of the prostaglandin E2 (PGE2) receptor subtype EP2.1 It reduces intraocular pressure (IOP) in ocular normotensive and laser-induced ocular hypertensive cynomolgus monkeys when topically administered at a concentration of 0.01%/eye.1,2 Formulations containing omidenepag isopropyl have been used in the treatment of open-angle glaucoma and ocular hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Iwamura, R., Tanaka, M., Okanari, E., et al. Identification of a selective, non-prostanoid EP2 receptor agonist for the treatment of glaucoma: Omidenepag and its prodrug omidenepag isopropyl. J. Med. Chem. 61(15), 6869-6891 (2018).

    2. Kirihara, T., Taniguchi, T., Yamamura, K., et al. Pharmacologic characterization of omidenepag isopropyl, a novel selective EP2 receptor agonist, as an ocular hypotensive agent. Invest. Ophthalmol. Vis. Sci. 59(1), 145-153 (2018).