A RIPK3 inhibitor
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UH15-38

Item No. 41056

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(3-hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one
CAS Number
2540881-21-6
Molecular Formula
C26H27N5O2
Formula Weight
441.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CN1CCN(C2=CC(NC3=NC=C4C(N(C)C(C(C5=CC(O)=CC=C5)=C4)=O)=C3)=CC=C2)CC1
InChi Code
InChI=1S/C26H27N5O2/c1-29-9-11-31(12-10-29)21-7-4-6-20(15-21)28-25-16-24-19(17-27-25)14-23(26(33)30(24)2)18-5-3-8-22(32)13-18/h3-8,13-17,32H,9-12H2,1-2H3,(H,27,28)
InChi Key
DLRROFRAOBFFEP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $95

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    5 mg

    $426

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    10 mg

    $710

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    25 mg

    $1,419

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    Product Description

    UH15-38 is an inhibitor of receptor-interacting serine/threonine kinase 3 (RIPK3; IC50 = 0.02 µM).1 It is selective for RIPK3 over a panel of 50 receptors and enzymes at 1 µM and a panel of 77 kinases at 0.5 µM but does inhibit RIPK1 (IC50 = 0.024 µM) and 13 other kinases by greater than 90% at 0.5 µM. UH15-38 inhibits LPS-induced necroptosis in RAW 264.7 macrophages and isolated mouse bone marrow-derived macrophages (BMDMs; IC50s = 17 and 22 nM, respectively) and TNF-α-induced necroptosis in recombinant human RIPK3-expressing HeLa cells, Fas-associated death domain protein knockout (FADD-/-) Jurkat cells, and U937 cells (IC50s = 722, 205, and 329 nM, respectively). In vivo, UH15-38 (30 mg/kg) increases survival, decreases lung injury and immune cell bronchoalveolar fluid (BALF) infiltration, and inhibits decreases in arterial oxygen saturation in a mouse model of severe influenza A infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gautam, A., Boyd, D.F., Nikhar, S., et al. Necroptosis blockade prevents lung injury in severe influenza. Nature 628(8009), 835-843 (2024).