An inactive derivative of PS-48
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PS-47

Item No. 41116

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(4-chlorophenyl)-3-phenyl-2E-pentenoic acid
CAS Number
1180676-33-8
Molecular Formula
C17H15ClO2
Formula Weight
286.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
OC(/C=C(CCC1=CC=C(Cl)C=C1)/C2=CC=CC=C2)=O
InChi Code
InChI=1S/C17H15ClO2/c18-16-10-7-13(8-11-16)6-9-15(12-17(19)20)14-4-2-1-3-5-14/h1-5,7-8,10-12H,6,9H2,(H,19,20)/b15-12+
InChi Key
LLJYFDRQFPQGNY-NTCAYCPXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $116

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    100 mg

    $185

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    250 mg

    $260

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    500 mg

    $462

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    Product Description

    PS-47 is an inactive derivative of the 3-phosphoinositide-dependent protein kinase 1 (PDK1) allosteric activator PS-48 that has been used as a negative control for the kinase activity of PDK1.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stroba, A., Schaeffer, F., Hindie, V., et al. 3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: Structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds. J. Med. Chem. 52(15), 4683-4693 (2009).

    2. Querfurth, H., Marshall, J., Parang, K., et al. A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro. PLoS One 17(1), e0261696 (2022).