An inhibitor of DPP-4
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DBPR108

Item No. 41117

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2S-[[1,1-dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl]amino]acetyl]-4S-fluoro-2-pyrrolidinecarbonitrile
CAS Number
1186426-66-3
Synonyms
  • Prusogliptin
Molecular Formula
C16H25FN4O2
Formula Weight
324.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
O=C(N1CCCC1)CC(C)(C)NCC(N2[C@H](C#N)C[C@H](F)C2)=O
InChi Code
InChI=1S/C16H25FN4O2/c1-16(2,8-14(22)20-5-3-4-6-20)19-10-15(23)21-11-12(17)7-13(21)9-18/h12-13,19H,3-8,10-11H2,1-2H3/t12-,13-/m0/s1
InChi Key
VQKSCYBKUIDZEI-STQMWFEESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $207

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    25 mg

    $491

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    50 mg

    $927

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    DBPR108 is an inhibitor of dipeptidyl peptidase 4 (DPP-4; IC50 = 0.015 µM).1 It is selective for DPP-4 over DPP-8 and DPP-9 (IC50s = >50 µM for both). DBPR108 (10 mg/kg) increases plasma levels of glucagon-like peptide 1 (GLP-1) and insulin in rats.2 It reduces blood glucose levels in an oral glucose tolerance test in mice when administered at a dose of 3 mg/kg.1 DBPR108 (0.1 mg/kg), alone and in combination with the biguanide metformin (Item No. 13118), decreases blood glucose levels in an oral glucose tolerance test in a mouse model of high-fat diet-induced obesity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yeh, T.-K., Tsai, T.-Y., Hsu, T., et al. (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg. Med. Chem. Lett. 20(12), 3596-3600 (2010).

    2. Yeh, K.-C., Yeh, T.-K., Huang, C.-Y., et al. DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity. Life Sci. 278, 119574 (2021).