An inhibitor of PI3K
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

GNE-490

Item No. 41120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-amino-4-methyl-5-pyrimidinyl)-α,α-dimethyl-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine-6-methanol
CAS Number
1033739-92-2
Molecular Formula
C18H22N6O2S
Formula Weight
386.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
OC(C)(C)C1=CC(N=C(C2=CN=C(N)N=C2C)N=C3N4CCOCC4)=C3S1
InChi Code
InChI=1S/C18H22N6O2S/c1-10-11(9-20-17(19)21-10)15-22-12-8-13(18(2,3)25)27-14(12)16(23-15)24-4-6-26-7-5-24/h8-9,25H,4-7H2,1-3H3,(H2,19,20,21)
InChi Key
SFWTVVNNVHWDEE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $94

    Add

    5 mg

    $328

    Add

    10 mg

    $515

    Add

    25 mg

    $1,052

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    GNE-490 is an inhibitor of PI3K (IC50s = 3.5, 25, 5.2, and 15 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively).1 It is selective for PI3K over mTOR (IC50 = 740 nM) and a panel of 142 kinases at 1 µM. GNE-490 (0.4 µM) reduces cell migration by, the number of vessel outgrowths from, and induces apoptosis in, human umbilical vein endothelial cells (HUVECs).2 It increases the length of circadian rhythms in zebrafish larvae.3 GNE-490 (30 mg/kg) decreases vascularization and tumor growth in a PC3 prostate cancer mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sutherlin, D.P., Sampath, D., Berry, M., et al. Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors. J. Med. Chem. 53(3), 1086-1097 (2010).

    2. Sampath, D., Oeh, J., Wyatt, S.K., et al. Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response. Neoplasia 15(7), 694-711 (2013).

    3. Mosser, E.A., Chiu, C.N., Tamai, T.K., et al. Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen. Sci. Rep. 9(1), 12405 (2019).