A TYK2 inhibitor
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Bayer 18

Item No. 41124

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1,1-dimethylethyl)-N′-[3-[[5-fluoro-4-[(2-hydroxy-1,1-dimethylethyl)amino]-2-pyrimidinyl]amino]phenyl]-urea
CAS Number
1251752-12-1
Molecular Formula
C19H27FN6O2
Formula Weight
390.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Sparingly Soluble: 1-10 mg/ml
SMILES
CC(C)(CO)NC1=NC(NC2=CC(NC(NC(C)(C)C)=O)=CC=C2)=NC=C1F
InChi Code
InChI=1S/C19H27FN6O2/c1-18(2,3)26-17(28)23-13-8-6-7-12(9-13)22-16-21-10-14(20)15(24-16)25-19(4,5)11-27/h6-10,27H,11H2,1-5H3,(H2,23,26,28)(H2,21,22,24,25)
InChi Key
DYNMZYFOSRSMAC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $102

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    5 mg

    $481

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    10 mg

    $759

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    25 mg

    $1,518

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    Product Description

    Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM).1 It is selective for TYK2 over JAK2, cyclin-dependent kinase 2 (Cdk2), and VEGFR2 (IC50s = 2,000, 1,790, and 3,520 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buchmann, B., Eis, K., Bothe, U., et al. Aminocabonylamino-substituted anilino-pyrimidine derivatives as Tyk inhibitors, their production and use as medicinal products. (2010).