A covalent UCH-L1 inhibitor and click chemistry reagent
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8RK64

Item No. 41148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-(2-azidoacetyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl]-1-cyano-3S-pyrrolidinecarboxamide
CAS Number
2705841-52-5
Molecular Formula
C14H16N8O2S
Formula Weight
360.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlDMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
[N-]=[N+]=NCC(N1CC2=C(CC1)N=C(S2)NC([C@@H]3CN(CC3)C#N)=O)=O
InChi Code
InChI=1S/C14H16N8O2S/c15-8-21-3-1-9(6-21)13(24)19-14-18-10-2-4-22(7-11(10)25-14)12(23)5-17-20-16/h9H,1-7H2,(H,18,19,24)/t9-/m0/s1
InChi Key
KIWKRCCIHSGWQS-VIFPVBQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $97

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    10 mg

    $180

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    25 mg

    $413

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    Product Description

    8RK64 is a covalent inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1; IC50 = 0.32 µM) and a click chemistry reagent.1 It is selective for UCH-L1 over UCH-L3 and UCH-L5 (IC50s = 216 and >1,000 µM, respectively). 8RK64 has been linked to fluorophores containing alkyne groups via copper(I)-catalyzed azide/alkyne cycloaddition (CuAAC) and used to visualize UCH-L1 activity in cells. See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kooij, R., Liu, S., Sapmaz, A., et al. Small-molecule activity-based probe for monitoring ubiquitin C-terminal hydrolase L1 (UCHL1) activity in live cells and zebrafish embryos. J. Am. Chem. Soc. 142(39), 16825-16841 (2020).