A multi-kinase inhibitor
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S49076 (hydrochloride)

Item No. 41173

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(3Z)-2,3-dihydro-3-[[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene]-2-oxo-1H-indol-5-yl]methyl]-2,4-thiazolidinedione, monohydrochloride
CAS Number
1265965-19-2
Molecular Formula
C22H22N4O4S • HCl
Formula Weight
475.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/ml
SMILES
O=C(/C(C1=C2)=C\C3=CC(CN4CCOCC4)=CN3)NC1=CC=C2CN5C(SCC5=O)=O.Cl
InChi Code
InChI=1S/C22H22N4O4S.ClH/c27-20-13-31-22(29)26(20)12-14-1-2-19-17(8-14)18(21(28)24-19)9-16-7-15(10-23-16)11-25-3-5-30-6-4-25;/h1-2,7-10,23H,3-6,11-13H2,(H,24,28);1H/b18-9-;
InChi Key
FPSAJUOIYZSJJA-NAIZSXBXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $159

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    10 mg

    $264

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    25 mg

    $616

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    Product Description

    S49076 is a multi-kinase inhibitor.1 It inhibits c-Met, Axl, Mer, FGFR1, FGFR2, and FGFR3 (IC50s = 1, 7, 2, 18, 17, and 15 nM, respectively). S49076 inhibits Axl- and c-Met-mediated Akt phosphorylation in MDA-MB-231 cells (IC50s = 33 and <3 nM, respectively). It also inhibits FGFR1, FGFR2, and FGFR3 autophosphorylation in NCI 1703, SNU-16, and RT-112 cells, respectively (IC50s = 50-200 nM). In vivo, S49076 (6.25-50 mg/kg) reduces mean tumor volume in GTL-16 and U87MG mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burbridge, M.F., Bossard, C.J., Saunier, C., et al. S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab. Mol. Cancer Ther. 12(9), 1749-1762 (2013).