An ionizable cationic lipid
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H1L1A1B3

Item No. 41199

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
dodecanoic acid, 7-(cyclohexylamino)-6-[[3-(dimethylamino)propyl](4-methyl-1-oxononyl)amino]-7-oxoheptyl ester
CAS Number
3097638-09-7
Molecular Formula
C40H77N3O4
Formula Weight
664.1
Purity
≥95%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
O=C(C(CCCCCOC(CCCCCCCCCCC)=O)N(CCCN(C)C)C(CCC(C)CCCCC)=O)NC1CCCCC1
InChi Code
InChI=1S/C40H77N3O4/c1-6-8-10-11-12-13-14-15-22-29-39(45)47-34-23-17-21-28-37(40(46)41-36-26-19-16-20-27-36)43(33-24-32-42(4)5)38(44)31-30-35(3)25-18-9-7-2/h35-37H,6-34H2,1-5H3,(H,41,46)
InChi Key
GIBXGBZJMJLFQW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $121

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    10 mg

    $230

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    25 mg

    $545

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    50 mg

    $1,029

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    Cayman Chemical
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    Product Description

    H1L1A1B3 is an ionizable cationic lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA) in vitro and in vivo.1 LNPs containing H1L1A1B3 and encapsulating circRNA encoding IL-12 induce IL-12 production four times more effectively than LNPs containing ALC-0315 (Item No. 34337) and encapsulating the same circRNA in LLC1 murine Lewis lung carcinoma cells. Administration of LNPs containing H1L1A1B3 and encapsulating circRNA encoding IL-12 reduces tumor growth in an LLC1 murine Lewis lung carcinoma model in combination with an antibody against programmed cell death ligand 1 (PD-L1).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, S., Xu, Y., Solek, N.C., et al. Tumor-tailored ionizable lipid nanoparticles facilitate IL-12 circular RNA delivery for enhanced lung cancer immunotherapy. Adv. Mater. 36(29), e2400307 (2024).