A tripeptide
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DT-109

Item No. 41219

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycylglycyl-L-leucine
CAS Number
14857-82-0
Synonyms
  • Gly-Gly-L-Leu
Molecular Formula
C10H19N3O4
Formula Weight
245.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
NCC(NCC(N[C@H](C(O)=O)CC(C)C)=O)=O
InChi Code
InChI=1S/C10H19N3O4/c1-6(2)3-7(10(16)17)13-9(15)5-12-8(14)4-11/h6-7H,3-5,11H2,1-2H3,(H,12,14)(H,13,15)(H,16,17)/t7-/m0/s1
InChi Key
XPJBQTCXPJNIFE-ZETCQYMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

    $28

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    5 g

    $110

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    10 g

    $207

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    DT-109 is a tripeptide.1 It reduces blood glucose levels in an oral glucose tolerance test (OGTT) in mice. DT-109 (1 mg/g per day) reduces non-fasting blood glucose levels, serum total cholesterol and LDL levels, and adipocyte hypertrophy in Apo-/- mice. It reduces body fat mass, adipocyte hypertrophy, and hepatomegaly in a mouse model of diet-induced non-alcoholic steatohepatitis (NASH). DT-109 (500 mg/kg per day) also reverses hepatic steatosis and prevents the progression of fibrosis in a cynomolgus monkey model of NASH induced by a high-fat, high-fructose, and high-cholesterol diet.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rom, O., Liu, Y., Liu, Z., et al. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. Sci. Transl. Med. 12(572), eaaz2841 (2020).

    2. Qu, P., Rom, O., Li, K., et al. DT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates. Cell Metab. 35(5), 742-757 (2023).