A cationic quaternary ammonium lipid derivative of ALC-0315
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Q1-ALC-0315 (iodide)

Item No. 41240

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[(2-hexyl-1-oxodecyl)oxy]-N-[6-[(2-hexyl-1-oxodecyl)oxy]hexyl]-N-(4-hydroxybutyl)-N-methyl-1-hexanaminium, monoiodide
CAS Number
3112713-48-8
Molecular Formula
C49H98NO5 • I
Formula Weight
908.2
Purity
≥98%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
OCCCC[N+](CCCCCCOC(C(CCCCCC)CCCCCCCC)=O)(C)CCCCCCOC(C(CCCCCC)CCCCCCCC)=O.[I-]
InChi Code
InChI=1S/C49H98NO5.HI/c1-6-10-14-18-20-28-38-46(36-26-16-12-8-3)48(52)54-44-34-24-22-30-40-50(5,42-32-33-43-51)41-31-23-25-35-45-55-49(53)47(37-27-17-13-9-4)39-29-21-19-15-11-7-2;/h46-47,51H,6-45H2,1-5H3;1H/q+1;/p-1
InChi Key
IHJMUQMUQJQQBU-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Q1-ALC-0315 is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid ALC-0315 (Item No. 34337) that has been used in the generation of lipid nanoparticles (LNPs) for use in vivo.1 LNPs containing Q1-ALC-0315 and ALC-0315 as a cationic lipid pair (CLP) and encapsulating mRNA encoding a luciferase reporter induce luciferase expression in the lungs and spleen in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zeng, G., He, Z., Yang, H., et al. Cationic lipid pairs enhance liver-to-lung tropism of lipid nanoparticles for in vivo mRNA delivery. ACS Appl. Mater. Interfaces 16(20), 25698-25709 (2024).