A TLK2 inhibitor
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UNC-CA2-103

Item No. 41241

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(Z)-N-(3-((4-methyl-1H-imidazol-5-yl)methylene)-2-oxoindolin-5-yl)benzamide
Synonyms
  • Inhibitor 128
Molecular Formula
C20H16N4O2
Formula Weight
344.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C1NC2=CC=C(NC(C3=CC=CC=C3)=O)C=C2/C1=C/C4=C(C)N=CN4
InChi Code
InChI=1S/C20H16N4O2/c1-12-18(22-11-21-12)10-16-15-9-14(7-8-17(15)24-20(16)26)23-19(25)13-5-3-2-4-6-13/h2-11H,1H3,(H,21,22)(H,23,25)(H,24,26)/b16-10-
InChi Key
FDJSILGLKCJVAQ-YBEGLDIGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $131

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    10 mg

    $248

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    Product Description

    UNC-CA2-103 is an inhibitor of tousled-like kinase 2 (TLK2; IC50 = 18 nM).1 It is selective for TLK2 over TLK1, tropomyosin-related kinase C (TrkC), and FMS-related tyrosine kinase 3 (FLT3) at 500 nM and a panel of 468 kinases at 1 µM, but it does inhibit 11 kinases by greater than 90% in the same panel.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Asquith, C.R.M., East, M.P., Laitinen, T., et al. Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships. BioRxiv 271(6), 116357 (2023).