A dual GLP-1R and GLP-2R agonist
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Dapiglutide (sodium salt)

Item No. 41259

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidyl-2-methylalanyl-L-α-glutamylglycyl-L-seryl-L-phenylalanyl-L-threonyl-L-seryl-L-α-glutamyl-L-leucyl-L-alanyl-L-threonyl-L-isoleucyl-L-leucyl-L-α-aspartyl-N6-[N-(17-carboxy-1-oxoheptadecyl)-L-γ-glutamyl]-L-lysyl-L-glutaminyl-L-alanyl-L-alanyl-L-arginyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-isoleucyl-L-glutaminyl-L-histidyl-L-lysyl-L-isoleucyl-L-threonyl-L-aspartic acid
Molecular Formula
C192H302N46O57 • XNa
Formula Weight
4166.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(O)C[C@@H](C(O)=O)NC([C@H]([C@H](O)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H](CC1=CNC=N1)NC([C@H](CCC(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CC4=CC=CC=C4)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@@](CCCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)(C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H]([C@H](O)C)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC5=CC=CC=C5)NC([C@H](CO)NC(CNC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC6=CNC=N6)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.[Na]
InChi Code
InChI=1S/C192H302N46O57.Na/c1-24-101(11)151(181(284)211-108(18)161(264)219-133(84-115-90-203-120-60-49-48-59-118(115)120)172(275)221-130(81-100(9)10)175(278)233-152(102(12)25-2)182(285)218-124(65-70-140(195)244)167(270)224-134(86-117-92-200-97-206-117)173(276)216-121(61-50-52-76-193)169(272)231-154(104(14)27-4)184(287)237-156(111(21)242)185(288)228-137(189(293)294)89-150(259)260)232-176(279)131(82-113-55-42-40-43-56-113)222-174(277)135(87-148(255)256)225-166(269)122(62-54-78-202-191(197)198)214-159(262)106(16)207-158(261)105(15)209-165(268)126(66-71-141(196)245)230-190(295)192(23,75-51-53-77-201-142(246)72-67-127(188(291)292)212-143(247)63-46-38-36-34-32-30-28-29-31-33-35-37-39-47-64-145(249)250)238-180(283)136(88-149(257)258)226-171(274)129(80-99(7)8)227-183(286)153(103(13)26-3)234-187(290)157(112(22)243)235-162(265)109(19)210-170(273)128(79-98(5)6)220-168(271)125(69-74-147(253)254)217-179(282)139(95-240)229-186(289)155(110(20)241)236-177(280)132(83-114-57-44-41-45-58-114)223-178(281)138(94-239)213-144(248)93-204-164(267)123(68-73-146(251)252)215-160(263)107(17)208-163(266)119(194)85-116-91-199-96-205-116;/h40-45,48-49,55-60,90-92,96-112,119,121-139,151-157,203,239-243H,24-39,46-47,50-54,61-89,93-95,193-194H2,1-23H3,(H2,195,244)(H2,196,245)(H,199,205)(H,200,206)(H,201,246)(H,204,267)(H,207,261)(H,208,266)(H,209,268)(H,210,273)(H,211,284)(H,212,247)(H,213,248)(H,214,262)(H,215,263)(H,216,276)(H,217,282)(H,218,285)(H,219,264)(H,220,271)(H,221,275)(H,222,277)(H,223,281)(H,224,270)(H,225,269)(H,226,274)(H,227,286)(H,228,288)(H,229,289)(H,230,295)(H,231,272)(H,232,279)(H,233,278)(H,234,290)(H,235,265)(H,236,280)(H,237,287)(H,238,283)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,291,292)(H,293,294)(H4,197,198,202);/t101-,102-,103-,104-,105-,106-,107-,108-,109-,110+,111+,112+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,151-,152-,153-,154-,155-,156-,157-,192-;/m0./s1
InChi Key
NARUMHROZSAYCJ-WCZJBORZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Dapiglutide is a dual glucagon-like peptide 1 receptor (GLP-1R) and GLP-2R agonist.1 It induces cAMP accumulation in HEK293 cells expressing human GLP-1R or GLP-2R (EC50s = 190 and 210 pM, respectively). Dapiglutide (6 nmol/kg) reduces peak blood glucose levels in an oral glucose tolerance test and increases intestinal wet weight in mice. It decreases gastric emptying and increases intestinal weight and length in rats (ED50s = 7.6, 20.7, and 10.7 nmol/kg, respectively). Dapiglutide also promotes body weight recovery, decreases stool water content, and increases intestinal villus height and intestinal length in a mouse model of short bowel and intestinal insufficiency induced by 40% ileocecal resection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reiner, J., Berlin, P., Held, J., et al. Dapiglutide, a novel dual GLP-1 and GLP-2 receptor agonist, attenuates intestinal insufficiency in a murine model of short bowel. JPEN J. Parenter. Enteral Nutr. 46(5), 1107-1118 (2022).