A dual peptide agonist of GCGR and GLP-1R
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Bamadutide

Item No. 41269

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-histidyl-D-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-N6-[N-(1-oxohexadecyl)-L-γ-glutamyl]-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-alanyl-L-alanyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-alanylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide
CAS Number
1596343-09-7
Synonyms
  • SAR425899
Molecular Formula
C200H313N51O63
Formula Weight
4440.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
HsQGTFTSDLSKQXESKAAQDFIEWLKAGGPSSGAPPPS-NH2 (X = (S)-4-carboxy-4-hexadecanoylamino-butyryl-lysine)
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mlWater: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(N1[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@@H](C)C(N2[C@H](C(N3[C@H](C(N4[C@H](C(N[C@@H](CO)C(N)=O)=O)CCC4)=O)CCC3)=O)CCC2)=O)=O)=O)=O)CO)=O)CCC1)CNC(CNC([C@H](C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC5=CNC6=C5C=CC=C6)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC7=CC=CC=C7)NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CCCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCC)=O)=O)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@H](O)C)NC([C@H](CC8=CC=CC=C8)NC([C@H]([C@H](O)C)NC(CNC([C@H](CCC(N)=O)NC([C@@H](CO)NC([C@H](CC9=CNC=N9)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C200H313N51O63/c1-14-16-17-18-19-20-21-22-23-24-25-26-33-62-153(265)221-130(200(313)314)66-72-152(264)210-78-43-39-57-124(223-176(289)127(65-71-151(207)263)228-174(287)123(56-38-42-77-203)226-189(302)142(101-256)242-181(294)132(84-106(5)6)232-183(296)137(90-161(276)277)236-190(303)144(103-258)244-196(309)164(113(13)260)247-186(299)134(86-115-50-31-28-32-51-115)237-195(308)163(112(12)259)245-156(268)95-214-170(283)125(63-69-149(205)261)227-187(300)140(99-254)239-169(282)119(204)88-117-92-209-104-216-117)175(288)229-128(67-73-158(270)271)179(292)241-141(100-255)188(301)225-122(55-37-41-76-202)173(286)220-109(9)167(280)218-110(10)168(281)222-126(64-70-150(206)262)177(290)235-136(89-160(274)275)184(297)233-133(85-114-48-29-27-30-49-114)185(298)246-162(107(7)15-2)194(307)230-129(68-74-159(272)273)178(291)234-135(87-116-91-211-120-53-35-34-52-118(116)120)182(295)231-131(83-105(3)4)180(293)224-121(54-36-40-75-201)172(285)219-108(8)166(279)213-93-154(266)212-96-157(269)248-79-44-58-145(248)192(305)243-143(102-257)191(304)240-139(98-253)171(284)215-94-155(267)217-111(11)197(310)250-81-46-60-147(250)199(312)251-82-47-61-148(251)198(311)249-80-45-59-146(249)193(306)238-138(97-252)165(208)278/h27-32,34-35,48-53,91-92,104-113,119,121-148,162-164,211,252-260H,14-26,33,36-47,54-90,93-103,201-204H2,1-13H3,(H2,205,261)(H2,206,262)(H2,207,263)(H2,208,278)(H,209,216)(H,210,264)(H,212,266)(H,213,279)(H,214,283)(H,215,284)(H,217,267)(H,218,280)(H,219,285)(H,220,286)(H,221,265)(H,222,281)(H,223,289)(H,224,293)(H,225,301)(H,226,302)(H,227,300)(H,228,287)(H,229,288)(H,230,307)(H,231,295)(H,232,296)(H,233,297)(H,234,291)(H,235,290)(H,236,303)(H,237,308)(H,238,306)(H,239,282)(H,240,304)(H,241,292)(H,242,294)(H,243,305)(H,244,309)(H,245,268)(H,246,298)(H,247,299)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,313,314)/t107-,108-,109-,110-,111-,112+,113+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140+,141-,142-,143-,144-,145-,146
InChi Key
JKAXPDWNZWDLSU-ZDOADQCSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Bamadutide is a peptide agonist of glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R).1 It induces cAMP accumulation in HEK293 cells expressing human GCGR or GLP-1R (EC50s = 1 and 3.5 pM, respectively). Bamadutide (0.1 mg/kg) reduces food intake in female mice. It decreases blood levels of glucose and hemoglobin A1c (HbA1c) in female db/db mice when administered at a dose of 0.1 mg/kg per day. Bamadutide (5 or 15 µg/kg twice per day) reduces body weight and total fat mass in male mice fed a high-fat diet.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Haack, T., Wagner, M., Henkel, B., et al. Extendin-4 derivatives as dual GLP1/glucagon agonists. (2014).